| Election Name: | 1978 United States Senate election in Kentucky |
| Country: | Kentucky |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1972 United States Senate election in Kentucky |
| Previous Year: | 1972 |
| Next Election: | 1984 United States Senate election in Kentucky |
| Next Year: | 1984 |
| Election Date: | November 7, 1978 |
| Nominee1: | Walter Dee Huddleston |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 290,730 |
| Percentage1: | 60.98% |
| Nominee2: | Louie Guenthner Jr. |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 175,766 |
| Percentage2: | 36.87% |
| Map Size: | 300px |
| U.S. Senator | |
| Before Election: | Walter Dee Huddleston |
| Before Party: | Democratic Party (United States) |
| After Election: | Walter Dee Huddleston |
| After Party: | Democratic Party (United States) |
The 1978 United States Senate election in Kentucky took place on November 7, 1978. Incumbent Senator Walter Dee Huddleston won reelection to a second term., this was the last time Democrats and/or anyone other than Mitch McConnell won the Class 2 Senate seat in Kentucky.