See main article: 2010 US Open (tennis).
Maikel Scheffers and Ronald Vink defeated Nicolas Peifer and Jon Rydberg in the final, 6–0, 6–0 to win the men's doubles wheelchair tennis title at the 2010 US Open.
Stéphane Houdet and Stefan Olsson were the defending champions, but were defeated by Scheffers and Vink in the semifinals.