See main article: 2012 Copa Sony Ericsson Colsanitas.
Lourdes Domínguez Lino was the defending champion, but lost in the second round to Mariana Duque-Mariño.
Lara Arruabarrena Vecino won the title, defeating Alexandra Panova in the final with the score of 6–2, 7–5.
All seeded players lost in the first or second round.