| Mode: | Women's Basketball |
| Year: | 2015–16 |
| Team: | Southern Miss Lady Eagles |
| Conference: | Conference USA |
| Short Conf: | C-USA |
| Record: | 14–16 |
| Conf Record: | 7–11 |
| Hc Year: | 12th |
| Asst Coach1: | Jordan Dupuy |
| Asst Coach2: | Alaura Sharp |
| Asst Coach3: | Pauline Love |
| Champion: | Lady Eagle Thanksgiving Tournament champions |
The 2015–16 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2015–16 NCAA Division I women's basketball season. The Lady Eagles, led by twelfth-year head coach Joye Lee-McNelis, played their home games at Reed Green Coliseum in Hattiesburg, Mississippi and were members of Conference USA (C-USA). They finished the season 14–16, 7–11 in C-USA play, to finish in a three-way tie for eighth place. They lost in the first round of the C-USA women's tournament to UAB.
| Increase in ranking | |||
| Decrease in ranking | |||
| No change | |||
| (RV) | Received votes |
|-!colspan=9 style="background:#F1C500; color:#000000;"| Exhibition|-!colspan=9 style="background:#F1C500; color:#000000;"| Non-conference regular season|-!colspan=9 style="background:#F1C500; color:#000000;"| Conference USA regular season|-!colspan=9 style="background:#F1C500; color:#000000;"| Conference USA women's tournamentSource:[1]