| Champ: |  Félix Auger-Aliassime |
| Runner: |  J. J. Wolf |
| Score: | 6–4, 6–4 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Edition: | 1st |
| Type: | singles doubles |
See main article: article and 2022 Firenze Open.
Félix Auger-Aliassime defeated J. J. Wolf in the final, 6–4, 6–4 to win the singles tennis title at the 2022 Firenze Open. It was his second ATP Tour singles title.[1]
This was the first edition of an ATP Tour event in Florence since 1994.[2]
The top four seeds received a bye into the second round.
