The 2022 Winston-Salem Open was a men's tennis tournament play on outdoor hard courts. It was the 53rd edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP Tour 250 Series of the 2022 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 21 through August 27, 2022. It was the last event on the 2022 US Open Series before the 2022 US Open.[1]
See main article: 2022 Winston-Salem Open – Singles.
Adrian Mannarino def. 
Laslo Đere, 7–6(7–1), 6–4See main article: 2022 Winston-Salem Open – Doubles.
Matthew Ebden / 
Jamie Murray def. Hugo Nys / 
Jan Zieliński, 6–4, 6–2| Event | W | F | SF | QF | Round of 16 | Round of 32 | Round of 48 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 10 | 0 | 5 | 3 | 0 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event[2] | W | F | SF | QF | Round of 16 | Round of 32 | Round of 48 | width=85 | Q2 | width=85 | Q1 |
| Singles | $100,475 | $57,660 | $33,115 | $19,125 | $10,925 | $6,420 | $3,905 | $2,070 | $1,145 | ||
| Doubles* | $39,530 | $20,700 | $11,690 | $6,780 | $4,000 |
| Country | Player | Rank† | Seed | |
|---|---|---|---|---|
| Grigor Dimitrov | 18 | 1 | ||
| Botic van de Zandschulp | 24 | 2 | ||
| Maxime Cressy | 32 | 4 | ||
 Italy | Lorenzo Musetti | 33 | 5 | |
 Georgia | Nikoloz Basilashvili | 34 | 6 | |
 Argentina | ||||
 Spain | Albert Ramos Viñolas | 40 | 8 | |
 Finland | Emil Ruusuvuori | 44 | 9 | |
| France | Benjamin Bonzi | 48 | 10 | |
| Ilya Ivashka | 49 | 11 | ||
| Spain | Pedro Martínez | 53 | 12 | |
| United Kingdom | Jack Draper | 55 | 13 | |
| Italy | Lorenzo Sonego | 56 | 14 | |
| Spain | Jaume Munar | 57 | 15 | |
| João Sousa | 59 | 16 |
The following players received wildcard entry into the singles main draw:
The following players received entry using a protected ranking:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Sebastián Báez → replaced by 
Márton Fucsovics
Alexander Bublik → replaced by Adrian Mannarino Pablo Carreño Busta → replaced by 
Taro Daniel
Hugo Dellien → replaced by Shintaro Mochizuki Tomás Martín Etcheverry → replaced by Michail Pervolarakis
Marcos Giron → replaced by Peter Gojowczyk Quentin Halys → replaced by Denis Kudla
Alex Molčan → replaced by John Millman Brandon Nakashima → replaced by Jack Draper Richard Gasquet Tommy Paul → replaced by Dušan Lajović Frances Tiafoe → replaced by Steve Johnson| Country | Player | Country | Player | Rank† | Seed | |
|---|---|---|---|---|---|---|
| Nikola Mektić | Mate Pavić | 23 | 1 | |||
| Ivan Dodig | Austin Krajicek | 31 | 2 | |||
| Australia | Matthew Ebden | United Kingdom | Jamie Murray | 54 | 3 | |
| United Kingdom | Lloyd Glasspool | Finland | Harri Heliövaara | 56 | 4 |
† Rankings are as of 15 August 2022.
The following pairs received wildcard entry into the doubles main draw :
Jan Zieliński Matthew Ebden / Max Purcell → replaced by Matthew Ebden / Jamie Murray
Santiago González / Andrés Molteni → replaced by Aleksandr Nedovyesov / 
Aisam-ul-Haq Qureshi Neal Skupski → replaced by Fabrice Martin / Jonny O'Mara
Sander Gillé / Joran Vliegen Jamie Murray / 
Bruno Soares → replaced by Nathaniel Lammons / Jackson Withrow
