ARHGEF4 explained
Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.[1] [2]
Function
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.[2]
Interactions
ARHGEF4 has been shown to interact with APC.[3]
References
Further reading
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
- Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R . Adenomatous polyposis coli (APC) is required for normal development of skin and thymus . PLOS Genet. . 2 . 9 . e146 . 2006 . 17002498 . 1564426 . 10.1371/journal.pgen.0020146 . free .
- Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K . Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration . Dev. Cell . 7 . 6 . 871–83 . 2005 . 15572129 . 10.1016/j.devcel.2004.10.017 . free .
- Kawasaki Y, Sato R, Akiyama T . Mutated APC and Asef are involved in the migration of colorectal tumour cells . Nat. Cell Biol. . 5 . 3 . 211–5 . 2003 . 12598901 . 10.1038/ncb937 . 22276128 .
- Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T . Asef, a link between the tumor suppressor APC and G-protein signaling . Science . 289 . 5482 . 1194–7 . 2000 . 10947987 . 10.1126/science.289.5482.1194 . 2000Sci...289.1194K .
Notes and References
- Thiesen S, Kübart S, Ropers HH, Nothwang HG . Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22 . Biochem Biophys Res Commun . 273 . 1 . 364–9 . Jul 2000 . 10873612 . 10.1006/bbrc.2000.2925 .
- Web site: Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4.
- Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T . Asef, a link between the tumor suppressor APC and G-protein signaling . Science . 289 . 5482 . 1194–7 . 2000 . 10947987 . 10.1126/science.289.5482.1194 . 2000Sci...289.1194K .