Astressin-B Explained

Iupac Name:Cyclo(30-33)(phenylalanyl(12)-norleucyl(21)-Cα-methylleucyl(2-7)-glutamyl(30)-lysyl(33)-norleucyl(38)-Cα-methyleucyl(40))acetyl-hCRF(9-41)
Pubchem:73350132
Chembl:2370918
Chemspiderid:59008829
C:183
H:305
N:47
O:55
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Stdinchikey:BGFHNAZIBICPLD-IXILWOCFSA-N

Astressin-B is a nonselective corticotropin releasing hormone antagonist that reduces the synthesis of adrenocorticotropic hormone and cortisol.[1]

It reduces the synthesis of adrenocorticotropic hormone and improves the sexual drive of rats under stressing conditions.[2]

Astressin-B is able to delay the emptying of solid food in mice.[3] Astressin-B can prevent the release of adrenocorticotropic hormone in mice due to shock, alcohol and endotoxemia.[4]

Treatment with astressin-B caused the sudden growth of hair in mice bred for a propensity for stress.[5]

Notes and References

  1. Vulliémoz NR, Xiao E, Xia-Zhang L, Rivier J, Ferin M . Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey . Endocrinology . 149 . 3 . 869–874 . March 2008 . 18063681 . 2275354 . 10.1210/en.2007-1350 .
  2. Miwa Y, Nagase K, Oyama N, Akino H, Yokoyama O . Effect of corticotropin-releasing factor receptor antagonist on psychologically suppressed masculine sexual behavior in rats . The Journal of Sexual Medicine . 8 . 3 . 688–695 . March 2011 . 20946165 . 10.1111/j.1743-6109.2010.02055.x .
  3. Wang L, Martínez V, Rivier JE, Taché Y . Peripheral urocortin inhibits gastric emptying and food intake in mice: differential role of CRF receptor 2 . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology . 281 . 5 . R1401-R1410 . November 2001 . 11641109 . 10.1152/ajpregu.2001.281.5.R1401 . free .
  4. Rivier CL, Grigoriadis DE, Rivier JE . Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors . Endocrinology . 144 . 6 . 2396–2403 . June 2003 . 12746300 . 10.1210/en.2002-0117 . free .
  5. Wang L, Million M, Rivier J, Rivier C, Craft N, Stenzel-Poore MP, Taché Y . CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice . PLOS ONE . 6 . 2 . e16377 . February 2011 . 21359208 . 3040186 . 10.1371/journal.pone.0016377 . Polymenis M . free . 2011PLoSO...616377W .