CACNA2D2 explained
Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.[1]
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
CACNA2D2 containing channels are blocked by amiodarone.[2]
See also
Further reading
- Donato R, Page KM, Koch D . The ducky2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression . J. Neurosci. . 26 . 48 . 12576–86 . 2006 . 17135419 . 10.1523/JNEUROSCI.3080-06.2006 . 1797058 . etal.
- Carboni GL, Gao B, Nishizaki M . CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity . Oncogene . 22 . 4 . 615–26 . 2003 . 12555074 . 10.1038/sj.onc.1206134 . 3484891. etal.
- Honorio S, Gordon K, MacCartney D . Identification of a single nucleotide polymorphism in the human alpha 2 delta 2 calcium channel subunit gene . Mol. Cell. Probes . 15 . 6 . 391–3 . 2002 . 11851383 . 10.1006/mcpr.2001.0382 . etal.
- Angeloni D, Duh FM, Wei MF . 38006979 . A G-to-A single nucleotide polymorphism in intron 2 of the human CACNA2D2 gene that maps at 3p21.3 . Mol. Cell. Probes . 15 . 2 . 125–7 . 2001 . 11292331 . 10.1006/mcpr.2000.0341 . etal. 11382/301708 . free .
- Lerman MI, Minna JD . The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium . Cancer Res. . 60 . 21 . 6116–33 . 2000 . 11085536 .
- Gao B, Sekido Y, Maximov A . Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2) . J. Biol. Chem. . 275 . 16 . 12237–42 . 2000 . 10766861 . 10.1074/jbc.275.16.12237 . 3484885. etal. free .
- Hobom M, Dai S, Marais E . Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit . Eur. J. Neurosci. . 12 . 4 . 1217–26 . 2000 . 10762351 . 10.1046/j.1460-9568.2000.01009.x . 82569498 . etal.
- Nagase T, Ishikawa K, Miyajima N . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 5 . 1 . 31–9 . 1998 . 9628581 . 10.1093/dnares/5.1.31 . etal. free .
Notes and References
- Web site: Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2.
- Web site: Amiodarone. Drugbank. 2019-05-28.