CALCOCO2 explained
Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.[1] [2]
The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by HSV-1 infection and may have a role in viral life cycles.
CALCOCO2 is an autophagy receptor, and loss of CALCOCO2 in human beta cells has been linked to autophagy-mediated altered insulin granule homeostasis. Thus, mutations in CALCOCO2 have been linked to type 2 diabetes risk.[3]
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Sternsdorf T, Jensen K, Züchner D, Will H . Cellular localization, expression, and structure of the nuclear dot protein 52 . The Journal of Cell Biology . 138 . 2 . 435–448 . July 1997 . 9230084 . 2138200 . 10.1083/jcb.138.2.435 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Florin L, Schäfer F, Sotlar K, Streeck RE, Sapp M . Reorganization of nuclear domain 10 induced by papillomavirus capsid protein L2 . Virology . 295 . 1 . 97–107 . March 2002 . 12033769 . 10.1006/viro.2002.1360 . free .
- Di Y, Li J, Zhang Y, He X, Lu H, Xu D, Ling J, Huo K, Wan D, Li YY, Gu J . 6 . HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins . Journal of Biochemistry . 133 . 6 . 713–718 . June 2003 . 12869526 . 10.1093/jb/mvg091 .
- Everett RD, Sourvinos G, Leiper C, Clements JB, Orr A . Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes . Journal of Virology . 78 . 4 . 1903–1917 . February 2004 . 14747555 . 369473 . 10.1128/JVI.78.4.1903-1917.2004 .
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . 6 . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–1332 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . 2005Natur.437.1173R .
- Morriswood B, Ryzhakov G, Puri C, Arden SD, Roberts R, Dendrou C, Kendrick-Jones J, Buss F . 6 . T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion . Journal of Cell Science . 120 . Pt 15 . 2574–2585 . August 2007 . 17635994 . 2621013 . 10.1242/jcs.007005 .
Notes and References
- Korioth F, Gieffers C, Maul GG, Frey J . Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment . The Journal of Cell Biology . 130 . 1 . 1–13 . July 1995 . 7540613 . 2120522 . 10.1083/jcb.130.1.1 .
- Web site: Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2.
- Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JE, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL . 6 . A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk . Nature Genetics . 54–65 . December 2022 . 55 . 1 . 36543916 . 10.1038/s41588-022-01261-2 . free . 9839450 .