CDC14A explained
Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.[1] [2] [3]
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
Interactions
CDC14A has been shown to interact with P53, de-phosphorylate p53 at Serine 315 and thereby stabilize p53.[4] S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation.[5]
Further reading
- Li L, Ljungman M, Dixon JE . The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 . J. Biol. Chem. . 275 . 4 . 2410–4 . 2000 . 10644693 . 10.1074/jbc.275.4.2410 . free .
- Bembenek J, Yu H . Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a . J. Biol. Chem. . 276 . 51 . 48237–42 . 2002 . 11598127 . 10.1074/jbc.M108126200 . free.
- Mailand N, Lukas C, Kaiser BK . Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation . Nat. Cell Biol. . 4 . 4 . 317–22 . 2002 . 11901424 . 10.1038/ncb777 . 28955777 . etal.
- Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK . Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase . Mol. Biol. Cell . 13 . 7 . 2289–300 . 2003 . 12134069 . 10.1091/mbc.01-11-0535 . 117313 .
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
- Gruneberg U, Neef R, Honda R . Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 . J. Cell Biol. . 166 . 2 . 167–72 . 2004 . 15263015 . 10.1083/jcb.200403084 . 2172317 . etal.
- Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
- Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP . Functional homology among human and fission yeast Cdc14 phosphatases . J. Biol. Chem. . 280 . 32 . 29144–50 . 2005 . 15911625 . 10.1074/jbc.M413328200 . free . 10366/157107 . free .
- Zhao H, Wang Q, Zhang H . UXT is a novel centrosomal protein essential for cell viability . Mol. Biol. Cell . 16 . 12 . 5857–65 . 2006 . 16221885 . 10.1091/mbc.E05-08-0705 . 1289427 . etal.
- Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
- Sanchez M, Galy B, Dandekar T . Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy . J. Biol. Chem. . 281 . 32 . 22865–74 . 2006 . 16760464 . 10.1074/jbc.M603876200 . etal. free .
- Paulsen MT, Starks AM, Derheimer FA . The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers . Mol. Cancer . 5 . 25 . 2006 . 16784539 . 10.1186/1476-4598-5-25 . 1524803 . etal . free .
- Esteban V, Vázquez-Novelle MD, Calvo E . Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320 . Cell Cycle . 5 . 24 . 2894–8 . 2007 . 17172867 . 10.4161/cc.5.24.3566. etal. free . 10261/60508 . free .
- Lanzetti L, Margaria V, Melander F . Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells . J. Biol. Chem. . 282 . 20 . 15258–70 . 2007 . 17371873 . 10.1074/jbc.M700914200 . etal. free .
- Yuan K, Hu H, Guo Z . Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression . J. Biol. Chem. . 282 . 37 . 27414–23 . 2007 . 17623655 . 10.1074/jbc.M703555200 . etal. free .
Notes and References
- Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE . A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast . J Biol Chem . 272 . 47 . 29403–6 . December 1997 . 9367992 . 10.1074/jbc.272.47.29403 . free .
- Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH . Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene . Genomics . 59 . 2 . 248–51 . September 1999 . 10409437 . 10.1006/geno.1999.5863 .
- Web site: Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae).
- Li . L . Ljungman M. Dixon J E . January 2000 . The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 at Serine 315 . J. Biol. Chem. . 275 . 4 . 2410–4 . 0021-9258. 10644693 . 10.1074/jbc.275.4.2410 . free .
- Li . Y . Cui K. Zhang Q . Li X . Lin X . Tang Y . Prochownik E . Li Y . July 2021 . FBXL6 degrades phosphorylated p53 to promote tumor growth . Cell Death Differ. . 28 . 7 . 2112–2125 . 1350-9047. 33568778 . 10.1038/s41418-021-00739-6 . 8257708 . free .