CNTNAP4 explained
Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.[1] [2]
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.
Further reading
- Kim JM, Lee KH, Jeon YJ . Identification of genes related to Parkinson's disease using expressed sequence tags . DNA Res. . 13 . 6 . 275–86 . 2007 . 17213182 . 10.1093/dnares/dsl016 . etal. free .
- Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
- Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
- Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
- Nagase T, Kikuno R, Hattori A . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 6 . 347–55 . 2001 . 11214970 . 10.1093/dnares/7.6.347 . etal. free .
- Auffray C, Behar G, Bois F . [IMAGE: molecular integration of the analysis of the human genome and its expression] . Comptes Rendus de l'Académie des Sciences, Série III . 318 . 2 . 263–72 . 1995 . 7757816 . etal.
Notes and References
- Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E . Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains . Mol Cell Neurosci . 20 . 2 . 283–97 . Jul 2002 . 12093160 . 10.1006/mcne.2002.1110 . 25024421 .
- Web site: Entrez Gene: CNTNAP4 contactin associated protein-like 4.