DGKA explained
Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.[1] [2] [3]
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
Further reading
[4]
- Topham MK, Prescott SM . Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions . J. Biol. Chem. . 274 . 17 . 11447–50 . 1999 . 10206945 . 10.1074/jbc.274.17.11447 . free .
- Schaap D . Purification, cDNA-cloning and expression of human diacylglycerol kinase . FEBS Lett. . 275 . 1–2 . 151–8 . 1991 . 2175712 . 10.1016/0014-5793(90)81461-V . de Widt J . van der Wal J . Vandekerckhove . Joel . Van Damme . Jose . Gussow . Detlef . Ploegh . Hidde L. . Van Blitterswijk . Whim J. . Van Der Bend . Rob L. . 45452518 . free .
- Flores I . Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation . J. Biol. Chem. . 271 . 17 . 10334–40 . 1996 . 8626603 . 10.1074/jbc.271.17.10334 . Casaseca T . Martinez-A C . Kanoh . H . Merida . I . free.
- Jones DR . Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol . J. Biol. Chem. . 274 . 24 . 16846–52 . 1999 . 10358029 . 10.1074/jbc.274.24.16846 . Pettitt TR . Sanjuán MA . Mérida . I . Wakelam . MJ . free.
- Sanjuán MA, Jones DR, Izquierdo M, Mérida I . Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling . J. Cell Biol. . 153 . 1 . 207–20 . 2001 . 11285286 . 10.1083/jcb.153.1.207 . 2185527 .
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
- Sanjuán MA . T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation . J. Immunol. . 170 . 6 . 2877–83 . 2003 . 12626538 . 10.4049/jimmunol.170.6.2877. Pradet-Balade B . Jones DR . Martínez-a . C . Stone . JC . Garcia-Sanz . JA . Mérida . I . free .
- Li J . Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins . Mol. Cell. Biol. . 23 . 21 . 7437–47 . 2003 . 14559993 . 10.1128/MCB.23.21.7437-7447.2003 . 207616 . Hawkins IC . Harvey CD . Jennings . J. L. . Link . A. J. . Patton . J. G. .
- Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
- Gronert K . A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage . J. Immunol. . 172 . 3 . 1856–61 . 2004 . 14734770 . 4318492 . 10.4049/jimmunol.172.3.1856. Kantarci A . Levy BD . Clish . CB . Odparlik . S . Hasturk . H . Badwey . JA . Colgan . SP . Van Dyke . TE .
- Verrier E . PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase . Circ. Res. . 94 . 11 . 1515–22 . 2004 . 15117825 . 10.1161/01.RES.0000130527.92537.06 . Wang L . Wadham C . Albanese . N . Hahn . C . Gamble . JR . Chatterjee . VK . Vadas . MA . Xia . P . 25057646 .
- Baldanzi G . Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro . Oncogene . 23 . 28 . 4828–38 . 2004 . 15122338 . 10.1038/sj.onc.1207633 . Mitola S . Cutrupi S . Filigheddu . Nicoletta . Van Blitterswijk . Wim J . Sinigaglia . Fabiola . Bussolino . Federico . Graziani . Andrea . free . 11379/21460 . free .
- Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
- Alonso R . Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes . J. Biol. Chem. . 280 . 31 . 28439–50 . 2005 . 15870081 . 10.1074/jbc.M501112200 . Rodríguez MC . Pindado J . Merino . E . Mérida . I . Izquierdo . M . free.
- Bacchiocchi R . Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase . Blood . 106 . 6 . 2175–82 . 2005 . 15928040 . 10.1182/blood-2005-01-0316 . Baldanzi G . Carbonari D . Capomagi . C . Colombo . E . Van Blitterswijk . WJ . Graziani . A . Fazioli . F . free .
- Yanagisawa K . Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation . Biochim. Biophys. Acta . 1771 . 4 . 462–74 . 2007 . 17276726 . 10.1016/j.bbalip.2006.12.008 . Yasuda S . Kai M . Imai . S . Yamada . K . Yamashita . T . Jimbow . K . Kanoh . H . Sakane . F .
External links
Notes and References
- Hart TC, Champagne C, Zhou J, Van Dyke TE . Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12 . Mamm Genome . 5 . 2 . 123–4 . Jun 1994 . 8180475 . 10.1007/BF00292343 . 305119 .
- Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ . Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis . Genomics . 22 . 1 . 246–7 . Dec 1994 . 7959783 . 10.1006/geno.1994.1376 . free .
- Web site: Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa.
- Kovalenko . A . Sanin . A . Kosmas . K . Zhang . L . Wang . J . Giannikou . K . Probst . CK . Hougard . TR . Rue . RW . Krymskaya . VP . Asara . JM . Lam . HC . Kwiatkowski . DJ . Henske . EP . Filippakis . H . Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex . Cancer Research . 2021 . 81 . 8 . 2086–2100 . 10.1158/0008-5472.CAN-20-2218 . 33593821. 8137542 .