DGKG explained
Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene.[1] [2]
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Further reading
- Brose N, Betz A, Wegmeyer H . Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. . Curr. Opin. Neurobiol. . 14 . 3 . 328–40 . 2004 . 15194113 . 10.1016/j.conb.2004.05.006 . 7070625 .
- Luo B, Regier DS, Prescott SM, Topham MK . Diacylglycerol kinases. . Cell. Signal. . 16 . 9 . 983–9 . 2005 . 15212759 . 10.1016/j.cellsig.2004.03.016 .
- Topham MK . Signaling roles of diacylglycerol kinases. . J. Cell. Biochem. . 97 . 3 . 474–84 . 2006 . 16288460 . 10.1002/jcb.20704 . 38850368 . free .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
- Yamada K, Sakane F, Matsushima N, Kanoh H . EF-hand motifs of alpha, beta and gamma isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes. . 321 . Biochem. J. . (Pt 1) . 59–64 . 1997 . Pt 1 . 9003401 . 10.1042/bj3210059. 1218036 .
- Stöhr H, Klein J, Gehrig A . Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). . Hum. Genet. . 104 . 1 . 99–105 . 1999 . 10071200 . 10.1007/s004390050917 . 19248400 . etal.
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
- Yamada K, Sakane F, Imai S . Regulatory role of diacylglycerol kinase gamma in macrophage differentiation of leukemia cells. . Biochem. Biophys. Res. Commun. . 305 . 1 . 101–7 . 2003 . 12732202 . 10.1016/S0006-291X(03)00713-7 . etal.
- Oyaizu K, Kantarci A, Maeda H . Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis. . J. Periodont. Res. . 38 . 5 . 488–95 . 2003 . 12941073 . 10.1034/j.1600-0765.2003.00680.x . etal.
- Tsushima S, Kai M, Yamada K . Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation. . J. Biol. Chem. . 279 . 27 . 28603–13 . 2004 . 15102830 . 10.1074/jbc.M314031200 . etal. free .
- Filosto M, Mancuso M, Tomelleri G . Hepato-cerebral syndrome: genetic and pathological studies in an infant with a dGK mutation. . Acta Neuropathol. . 108 . 2 . 168–71 . 2004 . 15150663 . 10.1007/s00401-004-0872-9 . 31732164 . etal.
- Batista EL, Warbington M, Badwey JA, Van Dyke TE . Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs). . J. Cell. Biochem. . 94 . 4 . 774–93 . 2005 . 15578578 . 10.1002/jcb.20356 . 114877 .
- Matsubara T, Shirai Y, Miyasaka K . Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus. . J. Biol. Chem. . 281 . 10 . 6152–64 . 2006 . 16407189 . 10.1074/jbc.M509873200 . etal. free . 20.500.14094/D1004334 . free .
- Yamaguchi Y, Shirai Y, Matsubara T . Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. . J. Biol. Chem. . 281 . 42 . 31627–37 . 2006 . 16905533 . 10.1074/jbc.M606992200 . etal. free . 20.500.14094/D2003002 . free .
Notes and References
- Kai M, Sakane F, Imai S, Wada I, Kanoh H . Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells . J Biol Chem . 269 . 28 . 18492–8 . Aug 1994 . 10.1016/S0021-9258(17)32336-0 . 8034597 . free .
- Web site: Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa.