DHR2 domain explained
DHR2 (DOCK homology region 2), also known as CZH2 or Docker2, is a protein domain of approximately 450-550 amino acids that is present in the DOCK family of proteins.[1] This domain functions as a guanine nucleotide exchange factor (GEF) domain for small G proteins of the Rho family.[2] DHR2 domains bear no significant similarity to the well described DH domain (Dbl homologous domain) present in other RhoGEFs such as Vav, P-Rex and TRIO. Indeed, the most divergent mammalian DHR2 domains share only 16-17% sequence similarity.
Further reading
- Côté JF, Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol.. 17. 8. 383–393. 2007. 17765544 . 2887429 . 10.1016/j.tcb.2007.05.001.
- Book: Côté JF, Vuori K. In Vitro Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains . Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. 406. 41–57. 2006. 16472648 . 10.1016/S0076-6879(06)06004-6. 9780121828110.
- Lu M, Kinchen JM, Rossman KL. GEF A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr. Biol.. 15. 4. 371–77. 2005. 15723800 . 10.1016/j.cub.2005.01.050. 14267018. etal. free. 2005CBio...15..371L .
Notes and References
- Meller N, Merlot S, Guda C . CZH proteins: a new family of Rho-GEFs . J. Cell Sci. . 118 . Pt 21 . 4937–46 . November 2005 . 16254241 . 10.1242/jcs.02671. free .
- Côté JF, Vuori K . Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity . J. Cell Sci. . 115 . Pt 24 . 4901–13. December 2002 . 12432077 . 10.1242/jcs.00219. free .