E4F1 explained
Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1] [2] [3]
Function
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]
Interactions
E4F1 has been shown to interact with:
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Fernandes ER, Rooney RJ . The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. . Mol. Cell. Biol. . 17 . 4 . 1890–1903 . 1997 . 9121437 . 232036 . 10.1128/mcb.17.4.1890.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Rooney RJ, Daniels RR, Jenkins NA, Gilbert DJ, Rothammer K, Morris SW, Higgs DR, Copeland NG . Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice. . Mamm. Genome . 9 . 4 . 320–323 . 1998 . 9530632 . 10.1007/s003359900758 . 31200297 .
- Kim ST, Lim DS, Canman CE, Kastan MB . Substrate specificities and identification of putative substrates of ATM kinase family members. . J. Biol. Chem. . 274 . 53 . 37538–37543 . 2000 . 10608806 . 10.1074/jbc.274.53.37538 . free .
- Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G . p53 is involved in the p120E4F-mediated growth arrest. . Oncogene . 19 . 2 . 188–199 . 2000 . 10644996 . 10.1038/sj.onc.1203250 . free .
- Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C . pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 14 . 7738–7743 . 2000 . 10869426 . 16614 . 10.1073/pnas.130198397 . 2000PNAS...97.7738F . free .
- Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF . Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. . J. Biol. Chem. . 278 . 7 . 4981–4989 . 2003 . 12446718 . 10.1074/jbc.M210978200 . free .
- Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F . Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. . Cancer Res. . 64 . 1 . 102–107 . 2004 . 14729613 . 10.1158/0008-5472.CAN-03-2622 . 13897912 .
- Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H . E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. . Am. J. Pathol. . 165 . 6 . 2019–2031 . 2005 . 15579445 . 1618705 . 10.1016/s0002-9440(10)63253-1 .
- Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Paul C, Lacroix M, Iankova I, Julien E, Schäfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C . The LIM-only protein FHL2 is a negative regulator of E4F1. . Oncogene . 25 . 40 . 5475–5484 . 2006 . 16652157 . 10.1038/sj.onc.1209567 . 19655591 .
- Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C . E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. . Cell . 127 . 4 . 775–788 . 2006 . 17110336 . 10.1016/j.cell.2006.09.031 . 542082 . free .
- Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P . The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. . EMBO Rep. . 8 . 7 . 671–677 . 2007 . 17557114 . 1905893 . 10.1038/sj.embor.7400983 .
Notes and References
- Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G . Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids . Cytogenet Cell Genet . 82 . 1–2 . 99–100 . November 1998 . 9763670 . 10.1159/000015075 . 46826484 .
- Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM . Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3 . Genome Res . 6 . 6 . 525–537 . December 1996 . 8828041 . 10.1101/gr.6.6.525 . free .
- Web site: Entrez Gene: E4F1 E4F transcription factor 1.
- Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF . Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition . J. Biol. Chem. . 278 . 7 . 4981–4989 . February 2003 . 12446718 . 10.1074/jbc.M210978200 . free .
- Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G . p53 is involved in the p120E4F-mediated growth arrest . Oncogene . 19 . 2 . 188–199 . January 2000 . 10644996 . 10.1038/sj.onc.1203250 . free .
- Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C . pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F . Proc. Natl. Acad. Sci. U.S.A. . 97 . 14 . 7738–7743 . July 2000 . 10869426 . 16614 . 10.1073/pnas.130198397 . 2000PNAS...97.7738F . free .