EIF3B explained
Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene.[1] [2]
Interactions
EIF3B has been shown to interact with P70-S6 Kinase 1[3] and EIF3A.[4] [5] [6]
See also
Further reading
- Kirken RA, Rui H, Evans GA, Farrar WL . Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit . J. Biol. Chem. . 268 . 30 . 22765–70 . 1993 . 10.1016/S0021-9258(18)41592-X . 7693677 . free .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
- Asano K, Kinzy TG, Merrick WC, Hershey JW . Conservation and diversity of eukaryotic translation initiation factor eIF3 . J. Biol. Chem. . 272 . 2 . 1101–9 . 1997 . 8995409 . 10.1074/jbc.272.2.1101 . free .
- Chaudhuri J, Chakrabarti A, Maitra U . Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1 . J. Biol. Chem. . 272 . 49 . 30975–83 . 1997 . 9388245 . 10.1074/jbc.272.49.30975 . free .
- Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . 1998 . 9822659 . 10.1074/jbc.273.48.31901 . free .
- Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1998 . 9847074 . 10.1101/gr.8.11.1097 . free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
- Lin L, Holbro T, Alonso G, Gerosa D, Burger MM . Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7 . J. Cell. Biochem. . 80 . 4 . 483–90 . 2001 . 11169732 . 10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B . 35848129 .
- Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, Donahue TF, Hinnebusch AG . Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation . EMBO J. . 20 . 9 . 2326–37 . 2001 . 11331597 . 125443 . 10.1093/emboj/20.9.2326 .
- Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .
- Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW . The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro . J. Biol. Chem. . 279 . 10 . 8946–56 . 2004 . 14688252 . 10.1074/jbc.M312745200 . free .
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
- Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
- ElAntak L, Tzakos AG, Locker N, Lukavsky PJ . Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit . J. Biol. Chem. . 282 . 11 . 8165–74 . 2007 . 17190833 . 10.1074/jbc.M610860200 . 2313046 . free .
Notes and References
- Méthot N, Rom E, Olsen H, Sonenberg N . The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 . J. Biol. Chem. . 272 . 2 . 1110–6 . February 1997 . 8995410 . 10.1074/jbc.272.2.1110 . free .
- Web site: Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa.
- Holz MK, Ballif BA, Gygi SP, Blenis J . mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events . Cell . 123 . 4 . 569–80 . November 2005 . 16286006 . 10.1016/j.cell.2005.10.024 . 11118504 . free .
- Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . October 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .
- Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC . mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin . EMBO J. . 25 . 8 . 1659–68 . April 2006 . 16541103 . 1440840 . 10.1038/sj.emboj.7601047 .
- Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . November 1998 . 9822659 . 10.1074/jbc.273.48.31901 . free .