GZMB explained
Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[1] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.
CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[2]
See also
Further reading
- . Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B. . Australian and New Zealand Journal of Medicine . 25 . 6 . 793–9 . 1996 . 8770355 . 10.1111/j.1445-5994.1995.tb02883.x.
- Cohen GM . Caspases: the executioners of apoptosis. . Biochem. J. . 326 . 1. 1–16 . 1997 . 9337844 . 10.1042/bj3260001. 1218630 .
- Trapani JA, Sutton VR . Granzyme B: pro-apoptotic, antiviral and antitumor functions. . Curr. Opin. Immunol. . 15 . 5 . 533–43 . 2004 . 14499262 . 10.1016/S0952-7915(03)00107-9 .
External links
- The MEROPS online database for peptidases and their inhibitors: S01.010
Notes and References
- Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS . Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14 . Hum Genet . 84 . 5 . 465–70 . May 1990 . 2323780 . 10.1007/bf00195821. 22245529 .
- Web site: Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1).