| Guadalupe Nuevo | |
| Settlement Type: | Barangay |
| Pushpin Map: | Metro Manila |
| Subdivision Type: | Country |
| Subdivision Name: | Philippines |
| Subdivision Type1: | Region |
| Subdivision Name1: | National Capital Region |
| Subdivision Type2: | City |
| Subdivision Name2: | Makati |
| Subdivision Type3: | District |
| Subdivision Name3: | 2nd district of Makati |
| Leader Title: | Barangay Captain |
| Leader Name: | German "Jerry" Sunga |
| Area Total Km2: | 0.57 |
| Population As Of: | 2020 |
| Population Footnotes: | [1] |
| Population Total: | 20,533 |
| Population Density Km2: | auto |
| Postal Code Type: | ZIP code |
| Postal Code: | 1212 |
| Area Code: | 2 |
| Coordinates: | 14.5587°N 121.0446°W |
| Blank Name: | PSGC |
| Blank Info: | 137602009 |
Guadalupe Nuevo (in Tagalog pronounced as /gwɐdɐˈlupɛ ˈnwɛbo/;) is one of the 23 barangays of Makati, Philippines. It is the easternmost barangay of the city and belongs to the second legislative district of Makati. It is surrounded by EDSA and the Pasig River to the north, Barangay Guadalupe Viejo to the west, Barangay Pinagkaisahan to the south, and Taguig to its east and south. The Guadalupe MRT station is located along the barangay's boundary with Guadalupe Viejo. Various terminals of jeepney routes are also located in this barangay, thus the area is a transport hub.[2] The old headquarters of Metropolitan Manila Development Authority is found in this barangay.