HNRPUL1 explained
Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene.[1] [2] [3]
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined.[3]
Interactions
HNRPUL1 has been shown to interact with BRD7 and PRMT2.[4]
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Bachi A, Braun IC, Rodrigues JP, etal . The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. . RNA . 6 . 1 . 136–58 . 2000 . 10668806 . 10.1017/S1355838200991994 . 1369901 .
- Herold A, Suyama M, Rodrigues JP, etal . TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. . Mol. Cell. Biol. . 20 . 23 . 8996–9008 . 2000 . 11073998 . 10.1128/MCB.20.23.8996-9008.2000 . 86553 .
- Kzhyshkowska J, Schütt H, Liss M, etal . Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. . Biochem. J. . 358 . Pt 2 . 305–14 . 2001 . 11513728 . 10.1042/0264-6021:3580305 . 1222062 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Brill LM, Salomon AR, Ficarro SB, etal . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
- Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
- Kzhyshkowska J, Kremmer E, Hofmann M, etal . Protein arginine methylation during lytic adenovirus infection. . Biochem. J. . 383 . Pt 2 . 259–65 . 2005 . 15242333 . 10.1042/BJ20040210 . 1134066 .
- Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Barral PM, Rusch A, Turnell AS, etal . The interaction of the hnRNP family member E1B-AP5 with p53. . FEBS Lett. . 579 . 13 . 2752–8 . 2005 . 15907477 . 10.1016/j.febslet.2005.03.095 . 28875660 . free .
- Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 11858/00-001M-0000-0010-8592-0 . free .
- Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Shiffman D, Rowland CM, Louie JZ, etal . Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. . Arterioscler. Thromb. Vasc. Biol. . 26 . 7 . 1613–8 . 2006 . 16690874 . 10.1161/01.ATV.0000226543.77214.e4 . free .
- Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
- Kollers S, Musilova P, Rubes J, Rocha D . Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. . Anim. Genet. . 37 . 6 . 595–6 . 2007 . 17121608 . 10.1111/j.1365-2052.2006.01516.x .
Notes and References
- Gabler S, Schutt H, Groitl P, Wolf H, Shenk T, Dobner T . E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs . J Virol . 72 . 10 . 7960–71 . Oct 1998 . 9733834 . 110131 . 10.1128/JVI.72.10.7960-7971.1998.
- Kzhyshkowska J, Rusch A, Wolf H, Dobner T . Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7 . Biochem J . 371 . Pt 2 . 385–93 . Apr 2003 . 12489984 . 1223277 . 10.1042/BJ20021281 .
- Web site: Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1.
- 10.1042/0264-6021:3580305 . Kzhyshkowska . J . Schütt H . Liss M . Kremmer E . Stauber R . Wolf H . Dobner T . Sep 2001 . Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 . Biochem. J. . 358 . Pt 2 . 305–14 . 0264-6021. 11513728 . 1222062 .