ICAM5 explained
Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.[1] [2] [3]
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
Interactions
ICAM5 has been shown to interact with PSEN1.[4]
Further reading
- Yoshihara Y, Mori K . Telencephalin: a neuronal area code molecule? . Neurosci. Res. . 21 . 2 . 119–24 . 1995 . 7724062 . 10.1016/0168-0102(94)90153-8 . 19931440 .
- Hayflick JS, Kilgannon P, Gallatin WM . The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions. . Immunol. Res. . 17 . 3 . 313–27 . 1998 . 9638475 . 10.1007/BF02786454 . 19901365 .
- Benson DL, Yoshihara Y, Mori K . Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule. . J. Neurosci. Res. . 52 . 1 . 43–53 . 1998 . 9556028 . 10.1002/(SICI)1097-4547(19980401)52:1<43::AID-JNR5>3.0.CO;2-K . 22675478 . free .
- Rieckmann P, Turner T, Kligannon P, Steinhoff BJ . Telencephalin as an indicator for temporal-lobe dysfunction. . Lancet . 352 . 9125 . 370–1 . 1998 . 9717930 . 10.1016/S0140-6736(05)60469-2 . 6255738 .
- Arii N, Mizuguchi M, Mori K, Takashima S . Development of telencephalin in the human cerebrum. . Microsc. Res. Tech. . 46 . 1 . 18–23 . 1999 . 10402269 . 10.1002/(SICI)1097-0029(19990701)46:1<18::AID-JEMT2>3.0.CO;2-G . 22133468 .
- Mizuno T, Yoshihara Y, Kagamiyama H, etal . Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia. . Brain Res. . 849 . 1–2 . 58–66 . 2000 . 10592287 . 10.1016/S0006-8993(99)01984-8 . 353053 .
- Tian L, Kilgannon P, Yoshihara Y, etal . Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. . Eur. J. Immunol. . 30 . 3 . 810–8 . 2000 . 10741396 . 10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X . free .
- Tian L, Nyman H, Kilgannon P, etal . Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. . J. Cell Biol. . 150 . 1 . 243–52 . 2000 . 10893271 . 10.1083/jcb.150.1.243 . 2185561 .
- Annaert WG, Esselens C, Baert V, etal . Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. . Neuron . 32 . 4 . 579–89 . 2002 . 11719200 . 10.1016/S0896-6273(01)00512-8 . 2096602 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Gevaert K, Goethals M, Martens L, etal . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
- Brill LM, Salomon AR, Ficarro SB, etal . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
- Cox DG, Hankinson SE, Hunter DJ . Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk. . Cancer Epidemiol. Biomarkers Prev. . 15 . 1 . 178–9 . 2006 . 16434609 . 10.1158/1055-9965.EPI-05-0790 . free .
Notes and References
- Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K . cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1 . J Biol Chem . 272 . 2 . 1156–63 . Feb 1997 . 8995416 . 10.1074/jbc.272.2.1156 . free .
- Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM . Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2 . Genomics . 54 . 2 . 328–30 . Jan 1999 . 9828136 . 10.1006/geno.1998.5565 .
- Web site: Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin.
- 10.1016/S0896-6273(01)00512-8 . Annaert . W G . Esselens C . Baert V . Boeve C . Snellings G . Cupers P . Craessaerts K . De Strooper B . Nov 2001 . Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins . Neuron . 32 . 4 . 579–89 . 0896-6273. 11719200 . 2096602 . free .