IRAK2 explained
Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[1] [2]
Function
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[2]
Interactions
IRAK2 has been shown to interact with TRAF6[3] and Myd88.[1] [3] [4]
Further reading
- Auron PE . The interleukin 1 receptor: ligand interactions and signal transduction . Cytokine & Growth Factor Reviews . 9 . 3–4 . 221–37 . 1999 . 9918122 . 10.1016/S1359-6101(98)00018-5 .
- Maschera B, Ray K, Burns K, Volpe F . Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB . The Biochemical Journal . 339 (Pt 2) . 2 . 227–31 . Apr 1999 . 10191251 . 1220149 . 10.1042/0264-6021:3390227 .
- Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z . IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family . The Journal of Biological Chemistry . 274 . 27 . 19403–10 . Jul 1999 . 10383454 . 10.1074/jbc.274.27.19403 . free .
- Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA . Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction . Nature . 413 . 6851 . 78–83 . Sep 2001 . 11544529 . 10.1038/35092578 . 2001Natur.413...78F . 4333764 .
- McDermott EP, O'Neill LA . Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1 . The Journal of Biological Chemistry . 277 . 10 . 7808–15 . Mar 2002 . 11744690 . 10.1074/jbc.M108133200 . free . 2262/33695 . free .
- Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM . Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function . The Journal of Biological Chemistry . 278 . 9 . 7607–16 . Feb 2003 . 12493773 . 10.1074/jbc.M210455200 . free .
- Bin LH, Xu LG, Shu HB . TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling . The Journal of Biological Chemistry . 278 . 27 . 24526–32 . Jul 2003 . 12721283 . 10.1074/jbc.M303451200 . free .
- Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI . Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter . Journal of Molecular Biology . 346 . 2 . 411–22 . Feb 2005 . 15670593 . 10.1016/j.jmb.2004.11.066 .
- Keating SE, Maloney GM, Moran EM, Bowie AG . IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination . The Journal of Biological Chemistry . 282 . 46 . 33435–43 . Nov 2007 . 17878161 . 10.1074/jbc.M705266200 . free .
Notes and References
- Muzio M, Ni J, Feng P, Dixit VM . IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling . Science . 278 . 5343 . 1612–5 . Nov 1997 . 9374458 . 10.1126/science.278.5343.1612 . 1997Sci...278.1612M .
- Web site: Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2.
- Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z . IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family . The Journal of Biological Chemistry . 274 . 27 . 19403–10 . Jul 1999 . 10383454 . 10.1074/jbc.274.27.19403 . free .
- Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA . Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction . Nature . 413 . 6851 . 78–83 . Sep 2001 . 11544529 . 10.1038/35092578 . 2001Natur.413...78F . 4333764 .