LARP6 explained
La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6), is a protein that in humans is encoded by the LARP6 gene.[1]
Clinical relevance
In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[2]
Further reading
- Cai L, Fritz D, Stefanovic L, Stefanovic B . Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen. . J. Mol. Biol. . 395 . 2 . 309–26 . 2010 . 19917293 . 10.1016/j.jmb.2009.11.020 . 2826804.
- Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
- Glenn HL, Wang Z, Schwartz LM . Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts. . Am. J. Physiol., Cell Physiol. . 298 . 1 . C46–55 . 2010 . 19889961 . 10.1152/ajpcell.00387.2009 . 2806151.
- Valavanis C, Wang Z, Sun D, etal . Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta . Gene . 393 . 1–2 . 101–9 . 2007 . 17383118 . 10.1016/j.gene.2007.01.033 . 2739619.
- Barbe L, Lundberg E, Oksvold P, etal . Toward a confocal subcellular atlas of the human proteome. . Mol. Cell. Proteomics . 7 . 3 . 499–508 . 2008 . 18029348 . 10.1074/mcp.M700325-MCP200 . free .
Notes and References
- Web site: Entrez Gene: La ribonucleoprotein domain family.
- Strawbridge RJ, Dupuis J, Prokopenko I, etal . Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes . Diabetes . 60. 10. 2624–34. August 2011 . 21873549 . 10.2337/db11-0415 . 3178302.