List of adverse effects of nilotinib explained
This is a list of adverse effects of the anti-cancer drug nilotinib, sorted by frequency of occurrence.[1] [2] [3] [4] [5] [6]
Very common
Very common (>10% incidence) adverse effects include:
Common
Common (1–10% incidence) adverse effects include:
- Constipation
- Diarrhoea
- Vomiting
- Upper abdominal pain
- Indigestion
- Joint pain
- Muscle spasms
- Pain in extremities
- Asthenia
- Peripheral oedema
- Folliculitis
- Upper respiratory tract infection (including pharyngitis, nasopharyngitis, rhinitis)
- Skin papilloma
- Eosinophilia
- Lymphopenia
- Insomnia
- Anxiety
- Depression
- Diabetes mellitus
- Hypercholesterolaemia
- Hyperlipidaemia
- Hypertriglyceridaemia
- Hyperglycaemia
- Loss of appetite
- Dizziness
- Hypoaesthesia
- Peripheral neuropathy
- Eye pruritus
- Conjunctivitis
- Dry eye (including xerophthalmia)
- Vertigo
- Flushing
- Hypertension
- Angina pectoris
- Arrhythmia (including atrioventricular block, tachycardia, atrial fibrillation, ventricular extrasystoles, bradycardia)
- QT interval prolonged
- Palpitations
- Cough
- Dyspnoea
- Abdominal distension
- Abdominal discomfort
- Taste changes
- Flatulence
- Abnormal liver function
- Bone pain
- Back pain
- Erythema
- Hyperhidrosis
- Contusion
- Acne
- Dermatitis (including allergic, exfoliative and acneiform)
- Night sweats
- Fever without an infectious cause
- Chest pain (including non-cardiac chest pain)
- Chest discomfort
- Decreased haemoglobin
- Increased blood amylase
- Increased blood alkaline phosphatase
- Gamma-glutamyltransferase increased
- Weight increased
- Increased blood insulin
- Increased lipoprotein (including very low density and high density)
Uncommon
Uncommon (0.1–1% incidence) adverse effects include:
Notes and References
- Web site: Complete Nilotinib information from Drugs.com. Drugs.com. 25 January 2014.
- Web site: Tasigna : EPAR - Product Information. European Medicines Agency. Novartis Europharm Ltd.. 18 October 2013. 25 January 2014.
- Web site: Novartis Pharmaceuticals UK Ltd. electronic Medicines Compendium. Tasigna 150mg Hard Capsules - Summary of Product Characteristics (SPC). 9 September 2013. 25 January 2014.
- Web site: TASIGNA® nilotinib. TGA eBusiness Services. 21 October 2013. 25 January 2014. PDF.
- Web site: Tasigna (nilotinib) dosing, indications, interactions, adverse effects, and more. Medscape Reference. WebMD. 25 January 2014.
- Book: Rossi, S . 978-0-9805790-9-3 . Australian Medicines Handbook . Adelaide . The Australian Medicines Handbook Unit Trust . 2013 . 2013 .
- Chan . J . Shah . P . Moguel-Cobos . G . Nilotinib-Induced Dystonia and Cognitive Deficits in a Neurologically Normal Patient with Chronic Myeloid Leukemia. . Case Reports in Neurological Medicine . 2019 . 2019 . 3679319 . 10.1155/2019/3679319 . 31781436 . 6875312 . free .
- Donatelli, C., D. Chongnarungsin, and R. Ashton. . Acute respiratory failure from nilotinib-associated diffuse alveolar hemorrhage. 24467220 . 10.3109/10428194.2014.887714 . 55 . 10 . Oct 2014 . Leuk Lymphoma . 2408–9. 43118790.