MAML1 explained
Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.[1] [2] [3]
Function
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[3]
Details on the activity of the N-terminal domain of Mastermind-like protein 1may be found under MamL-1.
Interactions
MAML1 has been shown to interact with EP300[4] [5] and NOTCH1.[6]
Further reading
- Alves-Guerra MC, Ronchini C, Capobianco AJ . Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. . Cancer Res. . 67 . 18 . 8690–8 . 2007 . 17875709 . 10.1158/0008-5472.CAN-07-1720 . free .
- Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V . The notch regulator MAML1 interacts with p53 and functions as a coactivator. . J. Biol. Chem. . 282 . 16 . 11969–81 . 2007 . 17317671 . 10.1074/jbc.M608974200 . free .
- Nam Y, Sliz P, Song L, Aster JC, Blacklow SC . Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. . Cell . 124 . 5 . 973–83 . 2006 . 16530044 . 10.1016/j.cell.2005.12.037 . 17809522 . free .
- Fryer CJ, White JB, Jones KA . Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. . Mol. Cell . 16 . 4 . 509–20 . 2005 . 15546612 . 10.1016/j.molcel.2004.10.014 . free .
- Nam Y, Weng AP, Aster JC, Blacklow SC . Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. . J. Biol. Chem. . 278 . 23 . 21232–9 . 2003 . 12644465 . 10.1074/jbc.M301567200 . free .
- Wallberg AE, Pedersen K, Lendahl U, Roeder RG . p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. . Mol. Cell. Biol. . 22 . 22 . 7812–9 . 2002 . 12391150 . 134732 . 10.1128/MCB.22.22.7812-7819.2002 .
- Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M . Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. . J. Biol. Chem. . 277 . 52 . 50612–20 . 2003 . 12386158 . 10.1074/jbc.M209529200 . free .
- Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA . Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. . Genes Dev. . 16 . 11 . 1397–411 . 2002 . 12050117 . 186317 . 10.1101/gad.991602 .
- Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J . SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. . Mol. Cell. Biol. . 21 . 21 . 7403–15 . 2001 . 11585921 . 99913 . 10.1128/MCB.21.21.7403-7415.2001 .
Notes and References
- Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD . MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors . Nat Genet . 26 . 4 . 484–9 . Dec 2000 . 11101851 . 10.1038/82644 . 23335042 .
- Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K . A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters . Mol Cell Biol . 21 . 13 . 4337–46 . Jun 2001 . 11390662 . 87094 . 10.1128/MCB.21.13.4337-4346.2001 .
- Web site: Entrez Gene: MAML1 mastermind-like 1 (Drosophila).
- Wallberg AE, Pedersen K, Lendahl U, Roeder RG . p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro . Mol. Cell. Biol. . 22 . 22 . 7812–9 . Nov 2002 . 12391150 . 134732 . 10.1128/MCB.22.22.7812-7819.2002 .
- Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA . Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex . Genes Dev. . 16 . 11 . 1397–411 . Jun 2002 . 12050117 . 186317 . 10.1101/gad.991602 .
- Wu L, Sun T, Kobayashi K, Gao P, Griffin JD . Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors . Mol. Cell. Biol. . 22 . 21 . 7688–700 . Nov 2002 . 12370315 . 135662 . 10.1128/MCB.22.21.7688-7700.2002 .