MYCBP2 explained
Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.[1] [2]
Structure
PAM contains a N-terminal leucine zipper, central MYC-binding, and C-terminal histone-binding protein homology domains.[1]
Interactions
MYCBP2 has been shown to interact with Myc.[1]
Further reading
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2002 . 12168954 . 10.1093/dnares/9.3.99 . free .
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 6 . 355–64 . 1998 . 10048485 . 10.1093/dnares/5.6.355 . free .
- Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
- Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V . Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex . J. Biol. Chem. . 279 . 2 . 1351–8 . 2004 . 14559897 . 10.1074/jbc.M310208200 . free .
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
- Pierre SC, Häusler J, Birod K, Geisslinger G, Scholich K . PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate . EMBO J. . 23 . 15 . 3031–40 . 2004 . 15257286 . 514936 . 10.1038/sj.emboj.7600321 .
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
- Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . free . 2004CBio...14.1436J .
- Gao X, Patel TB . Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity . Mol. Pharmacol. . 67 . 1 . 42–9 . 2005 . 15470080 . 10.1124/mol.104.005355 . 6049319 .
- Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
Notes and References
- Guo Q, Xie J, Dang CV, Liu ET, Bishop JM . Identification of a large Myc-binding protein that contains RCC1-like repeats . Proc. Natl. Acad. Sci. U.S.A. . 95 . 16 . 9172–7 . Sep 1998 . 9689053 . 21311 . 10.1073/pnas.95.16.9172 . 1998PNAS...95.9172G . free .
- Web site: Entrez Gene: MYCBP2 MYC binding protein 2.