MZF1 explained
Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.[1] [2]
Interactions
MZF1 has been shown to interact with SCAND1.[3] In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.[4] The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.[5]
Further reading
- Bavisotto L, Kaushansky K, Lin N, Hromas R . Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro . J. Exp. Med. . 174 . 5 . 1097–1101 . 1991 . 1719120 . 2119006 . 10.1084/jem.174.5.1097 .
- Sander TL, Haas AL, Peterson MJ, Morris JF . Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations . J. Biol. Chem. . 275 . 17 . 12857–12867 . 2000 . 10777584 . 10.1074/jbc.275.17.12857 . free .
- Peterson MJ, Morris JF . Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein . Gene . 254 . 1–2 . 105–118 . 2000 . 10974541 . 10.1016/S0378-1119(00)00281-X .
- Takahashi K, Matsumoto C, Ra C . FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1 . Biochem. J. . 386 . Pt 1 . 191–200 . 2005 . 15453830 . 1134781 . 10.1042/BJ20040775 .
- Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH . Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene . Mol. Cells . 18 . 2 . 157–62 . 2005 . 10.1016/S1016-8478(23)13096-2 . 15528990 . free .
- Le Mée S, Fromigué O, Marie PJ . Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts . Exp. Cell Res. . 302 . 1 . 129–142 . 2005 . 15541732 . 10.1016/j.yexcr.2004.08.028 .
- Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C . LDOC1, a novel MZF-1-interacting protein, induces apoptosis . FEBS Lett. . 579 . 3 . 604–608 . 2005 . 15670815 . 10.1016/j.febslet.2004.12.030 . 30914046 . free .
- Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY . PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells . Biochem. Biophys. Res. Commun. . 339 . 1 . 217–225 . 2006 . 16297876 . 10.1016/j.bbrc.2005.11.015 .
- Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF . Structure of the SCAN domain from the tumor suppressor protein MZF1 . J. Mol. Biol. . 363 . 1 . 137–147 . 2006 . 16950398 . 1941711 . 10.1016/j.jmb.2006.07.063 .
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
Notes and References
- Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K . A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells . J Biol Chem . 266 . 22 . 14183–7 . September 1991 . 10.1016/S0021-9258(18)98664-3 . 1860835 . free .
- Web site: Entrez Gene: MZF1 myeloid zinc finger 1.
- Sander TL, Haas AL, Peterson MJ, Morris JF . Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations . J. Biol. Chem. . 275 . 17 . 12857–12867 . April 2000 . 10777584 . 10.1074/jbc.275.17.12857 . free .
- Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH . The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol . Biochem. Biophys. Res. Commun. . 451 . 1 . 137–41 . 2014 . 25065746 . 10.1016/j.bbrc.2014.07.082 .
- 10.1002/jcp.25021 . 25899830 . 230 . 11 . Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment . Journal of Cellular Physiology . 2634–2639 . Piszczatowski RT. 2015 . 6888015 . free .