Mir-449 microRNA precursor family explained
miR-449 |
Symbol: | miR-449 |
Rfam: | RF00711 |
Mirbase Family: | MIPF0000133 |
Rna Type: | microRNA |
Tax Domain: | Eukaryota
|
In molecular biology, microRNAs function to regulate the expression levels of other genes by several mechanisms. The miR-449 microRNA family encompasses three homologous small RNA molecules (miR-449a/b/c). This miR-449 cluster is located in the second intron of the CDC20B gene which both are co-transcribed.[1] This miR-449 family belongs to the miR-34/miR-449 superfamily of microRNAs that is composed of six homologous miRNAs, named miR-34a/b/c and miR-449a/b/c.[2] They are grouped together in the same superfamily, as their seed region and their adjacent nucleotide sequences are largely conserved. The miR-449 miRNAs control the differentiation of multiciliated cells in vertebrates.
See also
Further reading
- Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kühnel F, Skawran B . Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells . Gastroenterology . 143 . 3 . 811–820.e15 . September 2012 . 22641068 . 10.1053/j.gastro.2012.05.033 .
- Bao J, Li D, Wang L, Wu J, Hu Y, Wang Z, Chen Y, Cao X, Jiang C, Yan W, Xu C . MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway . The Journal of Biological Chemistry . 287 . 26 . 21686–98 . June 2012 . 22570483 . 3381132 . 10.1074/jbc.M111.328054 . free .
- Ma YY, Tao HQ . Microribonucleic acids and gastric cancer . Cancer Science . 103 . 4 . 620–5 . April 2012 . 22168593 . 10.1111/j.1349-7006.2011.02185.x . 7713626 . free .
- Lizé M, Klimke A, Dobbelstein M . MicroRNA-449 in cell fate determination . Cell Cycle . 10 . 17 . 2874–82 . September 2011 . 21857159 . 10.4161/cc.10.17.17181 . 11858/00-001M-0000-000F-00E9-4 . free .
- Marcet B, Chevalier B, Coraux C, Kodjabachian L, Barbry P . MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation . Cell Cycle . 10 . 17 . 2858–64 . September 2011 . 21857154 . 10.4161/cc.10.17.17011 . free .
- Buechner J, Tømte E, Haug BH, Henriksen JR, Løkke C, Flægstad T, Einvik C . Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma . British Journal of Cancer . 105 . 2 . 296–303 . July 2011 . 21654684 . 3142803 . 10.1038/bjc.2011.220 .
- Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P . Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway . Nature Cell Biology . 13 . 6 . 693–9 . June 2011 . 21602795 . 10.1038/ncb2241 . 11514412 .
- Chevalier B, Adamiok A, Mercey O, Revinski DR, Zaragosi LE, Pasini A, Kodjabachian L, Barbry P, Marcet B . "miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways" . Nature Communications . 18 . 6 . 8386 . September 2015 . 26381333 . 10.1038/ncomms9386 . 4595761 . 2015NatCo...6.8386C . free .
- Mercey O, Popa A, Cavard A, Paquet A, Chevalier B, Pons N, Magnone V, Zangari J, Brest P, Zaragosi LE, Ponzio G, Lebrigand K, Barbry P, Marcet B . "Characterizing isomiR variants within the microRNA-34/449 family" . FEBS Letters . 591 . 5 . 693–705 . March 2017 . 28192603 . 10.1002/1873-3468.12595 . 5363356 . free .
- Mercey O, Chevalier, B, Kodjabachian L, Barbry P, Marcet B . "MicroRNAs pull the strings of motile cilia (Des microARN au Coeur de la fabrication des cils motiles)" . Médecine/Sciences . 31 . 12 . 1078–1080 . December 2015 . 10.1051/medsci/20153112010 . 26672659 . free .
- Mercey O, Kodjabachian L, Barbry P, Marcet B . "MicroRNAs as new regulators of GTPase-mediated apical actin reorganization in multiciliated epithelia" . Journal of Small GTPases . 7 . 2 . 54–8 . 2016 . 10.1080/21541248.2016.1151099 . 27144998 . 4905265 .
- Bou Kheir T, Futoma-Kazmierczak E, Jacobsen A, Krogh A, Bardram L, Hother C, Grønbæk K, Federspiel B, Lund AH, Friis-Hansen L . miR-449 inhibits cell proliferation and is down-regulated in gastric cancer . Molecular Cancer . 10 . 29 . March 2011 . 21418558 . 3070685 . 10.1186/1476-4598-10-29 . free .
- Ma L, Li N, He X, Zhang Q . [miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line] . Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences . 43 . 1 . 129–33 . February 2011 . 21321636 .
- Wang XY, Wu MH, Liu F, Li Y, Li N, Li GY, Shen SR . Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells . Molecular and Cellular Biochemistry . 345 . 1–2 . 283–90 . December 2010 . 20859756 . 10.1007/s11010-010-0582-7 . 27292546 .
- Feng M, Yu Q . miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit . Cell Cycle . 9 . 2 . 213–4 . January 2010 . 20046097 . 10.4161/cc.9.2.10502 . free .
- Campanini ML, Colli LM, Paixao BM, Cabral TP, Amaral FC, Machado HR, Neder LS, Saggioro F, Moreira AC, Antonini SR, de Castro M . CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas . Hormones & Cancer . 1 . 4 . 187–96 . August 2010 . 21761366 . 10.1007/s12672-010-0041-7 . 10358030 . free .
- Lizé M, Pilarski S, Dobbelstein M . E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis . Cell Death and Differentiation . 17 . 3 . 452–8 . March 2010 . 19960022 . 10.1038/cdd.2009.188 . free . 11858/00-001M-0000-0011-E2F8-7 . free .
- Greco S, De Simone M, Colussi C, Zaccagnini G, Fasanaro P, Pescatori M, Cardani R, Perbellini R, Isaia E, Sale P, Meola G, Capogrossi MC, Gaetano C, Martelli F . Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia . FASEB Journal . 23 . 10 . 3335–46 . October 2009 . 19528256 . 10.1096/fj.08-128579 . free . 36872281 .
- Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA . MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling . Cancer Research . 69 . 8 . 3278–82 . April 2009 . 19351815 . 3124768 . 10.1158/0008-5472.CAN-09-0155 .
- Wu W, Lin Z, Zhuang Z, Liang X . Expression profile of mammalian microRNAs in endometrioid adenocarcinoma . European Journal of Cancer Prevention . 18 . 1 . 50–5 . February 2009 . 19077565 . 10.1097/CEJ.0b013e328305a07a . 205549917 .
Notes and References
- Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P. . 2011 . "Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway". . . 13 . 6 . 693–9 . 10.1038/ncb2241. 21602795 . 11514412 .
- Ioannis Loukas, Margarita Skamnelou, Stavroula Tsaridou, Spyridoula Bournaka, Sokratis Grigoriadis, Stavros Taraviras, Zoi Lygerou and Marina Arbi . 2021 . Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members . . 96 . 5 . 2321–2332 . 10.1111/brv.12755. 34132477 . 235449908 .