N-acetylmuramoyl-L-alanine amidase explained
N-acetylmuramoyl-L-alanine amidase |
Ec Number: | 3.5.1.28 |
Cas Number: | 9013-25-6 |
Go Code: | 0008745 |
Symbol: | Amidase_2 |
Amidase_2 |
Pfam: | PF01510 |
Interpro: | IPR002502 |
Scop: | 1lba |
Symbol: | Amidase_3 |
Amidase_3 |
Pfam: | PF01520 |
Pfam Clan: | CL0035 |
Interpro: | IPR002508 |
Scop: | 1jwq |
Symbol: | Amidase_5 |
Amidase_5 |
Pfam: | PF05382 |
Pfam Clan: | CL0125 |
Interpro: | IPR008044 |
Symbol: | Amidase02_C |
Amidase02_C |
Pfam: | PF12123 |
Interpro: | IPR021976 |
In enzymology, a N-acetylmuramoyl-L-alanine amidase is an enzyme that catalyzes a chemical reaction that cleaves the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
This enzyme belongs to the family of hydrolases, specifically those acting on carbon-nitrogen bonds other than peptide bonds in linear amides. The systematic name of this enzyme class is peptidoglycan amidohydrolase. Other names in common use include acetylmuramyl-L-alanine amidase, N-acetylmuramyl-L-alanine amidase, N-acylmuramyl-L-alanine amidase, acetylmuramoyl-alanine amidase, N-acetylmuramic acid L-alanine amidase, acetylmuramyl-alanine amidase, N-acetylmuramylalanine amidase, N-acetylmuramoyl-L-alanine amidase type I, and N-acetylmuramoyl-L-alanine amidase type II. This enzyme participates in peptidoglycan biosynthesis. Autolysins and some phage lysins are examples of N-acetylmuramoyl-L-alanine amidases.
See also
References
- Campbell JN . 1969 . An improved technique for the preparation of Streptomyces peptidases and N-acetylmuramyl-l-alanine amidase active on bacterial wall peptidoglycans . Biochemistry . 8 . 213 - 22 . 5777325 . 10.1021/bi00829a031 . Dierickx . L . Coyette . J . Leyh-Bouille . M . Guinand . M . Campbell . JN . 1 .
- Herbold DR, Glaser L . 1975 . Interaction of N-acetylmuramic acid L-alanine amidase with cell wall polymers . J. Biol. Chem. . 250 . 7231 - 8 . 809432 . 18 .
- Herbold DR, Glaser L . 1975 . Bacillus subtilis N-acetylmuramic acid L-alanine amidase . J. Biol. Chem. . 250 . 1676 - 82 . 803507 . 5 .
- Ward JB, Curtis CA, Taylor C, Buxton RS . 1982 . Purification and characterization of two phage PBSX-induced lytic enzymes of Bacillus subtilis 168: an N-acetylmuramoyl-L-alanine amidase and an N-acetylmuramidase . J. Gen. Microbiol. . 128 . 1171 - 8 . 6126517 . 6 . 10.1099/00221287-128-6-1171. free .