NDRG4 explained
Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.[1] [2] [3]
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]
Further reading
- Nakajima D . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . vanc. Okazaki N . Yamakawa H . 3 . Kikuno . R . Ohara . O . Nagase . T . free .
- Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . vanc. Wentland MA . Ricafrente JY . 3 . Liu . W . Gibbs . RA .
- Yu W . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . vanc. Andersson B . Worley KC . 3 . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
- Hirosawa M . Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain . DNA Res. . 6 . 5 . 329–36 . 2000 . 10574461 . 10.1093/dnares/6.5.329 . vanc. Nagase T . Ishikawa K . 3 . Kikuno . R . Nomura . N . Ohara . O . free .
- Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
- Wiemann S . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . vanc. Weil B . Wellenreuther R . 3 . Gassenhuber . J . Glassl . S . Ansorge . W . Böcher . M . Blöcker . H . Bauersachs . S .
- Qu X . Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family . Mol. Cell. Biochem. . 229 . 1–2 . 35–44 . 2002 . 11936845 . 10.1023/A:1017934810825 . vanc. Zhai Y . Wei H . 3 . Zhang . Chenggang . Xing . Guichun . Yu . Yongtao . He . Fuchu . 24226208 .
- Ohki T . Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells . Brain Res. Dev. Brain Res. . 135 . 1–2 . 55–63 . 2002 . 11978393 . 10.1016/S0165-3806(02)00300-0 . vanc. Hongo S . Nakada N . 3 . Maeda . A . Takeda . M .
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
- Nishimoto S . A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells . Eur. J. Biochem. . 270 . 11 . 2521–31 . 2003 . 12755708 . 10.1046/j.1432-1033.2003.03626.x . vanc. Tawara J . Toyoda H . 3 . Kitamura . Kunihiro . Komurasaki . Toshi . free.
- Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
- Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
- Wiemann S . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . vanc. Arlt D . Huber W . 3 . Wellenreuther . R . Schleeger . S . Mehrle . A . Bechtel . S . Sauermann . M . Korf . U .
- Mehrle A . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . vanc. Rosenfelder H . Schupp I . 3 . Del Val . C . Arlt . D . Hahne . F . Bechtel . S . Simpson . J . Hofmann . O .
Notes and References
- Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T . Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart . Genomics . 73 . 1 . 86–97 . May 2001 . 11352569 . 10.1006/geno.2000.6496 .
- Hongo S, Watanabe T, Takahashi K, Miyazaki A . Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation . J Cell Biochem . 98 . 1 . 185–93 . Apr 2006 . 16408304 . 10.1002/jcb.20763 . 10192022 .
- Web site: Entrez Gene: NDRG4 NDRG family member 4.