NPTXR explained
Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.[1] [2]
This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.[3]
See also
- NPTX2, Neuronal pentraxin II
Further reading
- Poulsen TT, Pedersen N, Perin MS, etal . Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. . Lung Cancer . 50 . 3 . 329–37 . 2006 . 16115696 . 10.1016/j.lungcan.2005.06.011 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS . Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. . J. Biol. Chem. . 275 . 23 . 17786–92 . 2000 . 10748068 . 10.1074/jbc.M002254200 . free .
- Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22. . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
- Dodds DC, Omeis IA, Cushman SJ, etal . Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. . J. Biol. Chem. . 272 . 34 . 21488–94 . 1997 . 9261167 . 10.1074/jbc.272.34.21488 . free .
- Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
- Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
Notes and References
- Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G . Regulation of neuronal type genes in congestive heart failure rats . Acta Physiol (Oxf) . 186 . 1 . 17–27 . Feb 2006 . 16497176 . 10.1111/j.1748-1716.2005.01503.x . 46217094 .
- Web site: Entrez Gene: NPTXR neuronal pentraxin receptor.
- Web site: Entrez Gene: NPTXR neuronal pentraxin receptor.