SCN3A explained
Sodium channel, voltage-gated, type III, alpha subunit (SCN3A) is a protein that in humans is encoded by the SCN3A gene.[1] [2]
Function
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
SCN3A is involved in gyrification – the folding of the human cerebral cortex, and affects speech production brain areas.[3]
Further reading
- Catterall WA, Goldin AL, Waxman SG . International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels . Pharmacological Reviews . 57 . 4 . 397–409 . December 2005 . 16382098 . 10.1124/pr.57.4.4 . 7332624 .
- Malo MS, Srivastava K, Andresen JM, Chen XN, Korenberg JR, Ingram VM . Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31 . Proceedings of the National Academy of Sciences of the United States of America . 91 . 8 . 2975–9 . April 1994 . 8159690 . 43497 . 10.1073/pnas.91.8.2975 . 1994PNAS...91.2975M . free .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
- Lu CM, Brown GB . Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit . Journal of Molecular Neuroscience . 10 . 1 . 67–70 . February 1998 . 9589372 . 10.1007/BF02737087 . 2533542 .
- Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 7 . 1 . 65–73 . February 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
- Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J . Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction . The Journal of Biological Chemistry . 275 . 33 . 25616–24 . August 2000 . 10827173 . 10.1074/jbc.M000955200 . free .
- Chen YH, Dale TJ, Romanos MA, Whitaker WR, Xie XM, Clare JJ . Cloning, distribution and functional analysis of the type III sodium channel from human brain . The European Journal of Neuroscience . 12 . 12 . 4281–9 . December 2000 . 11122339 . 10.1046/j.1460-9568.2000.01336.x .
- Kasai N, Fukushima K, Ueki Y, Prasad S, Nosakowski J, Sugata K, Sugata A, Nishizaki K, Meyer NC, Smith RJ . Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus . Gene . 264 . 1 . 113–22 . February 2001 . 11245985 . 10.1016/S0378-1119(00)00594-1 .
- Whitaker WR, Faull RL, Dragunow M, Mee EW, Emson PC, Clare JJ . Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus . Neuroscience . 106 . 2 . 275–85 . 2001 . 11566500 . 10.1016/S0306-4522(01)00212-3 . 26385238 .
- Weiss LA, Escayg A, Kearney JA, Trudeau M, MacDonald BT, Mori M, Reichert J, Buxbaum JD, Meisler MH . Sodium channels SCN1A, SCN2A and SCN3A in familial autism . Molecular Psychiatry . 8 . 2 . 186–94 . February 2003 . 12610651 . 10.1038/sj.mp.4001241 . 16606651 .
- Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG . Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface . The Journal of Neuroscience . 24 . 33 . 7387–99 . August 2004 . 15317864 . 10.1523/JNEUROSCI.0322-04.2004 . 6729770 . free .
- Thimmapaya R, Neelands T, Niforatos W, Davis-Taber RA, Choi W, Putman CB, Kroeger PE, Packer J, Gopalakrishnan M, Faltynek CR, Surowy CS, Scott VE . Distribution and functional characterization of human Nav1.3 splice variants . The European Journal of Neuroscience . 22 . 1 . 1–9 . July 2005 . 16029190 . 10.1111/j.1460-9568.2005.04155.x . 30185095 .
- Platoshyn O, Remillard CV, Fantozzi I, Sison T, Yuan JX . Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells . Pflügers Archiv . 451 . 2 . 380–387 . November 2005 . 16052353 . 1351366 . 10.1007/s00424-005-1478-3 .
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
- Martin MS, Tang B, Ta N, Escayg A . Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences . Genomics . 90 . 2 . 225–35 . August 2007 . 17544618 . 2637551 . 10.1016/j.ygeno.2007.04.006 .
Notes and References
- Web site: UniProt . www.uniprot.org . 24 July 2022.
- Web site: Entrez Gene: SCN3A sodium channel, voltage-gated, type III, alpha subunit.
- Smith RS, Kenny CJ, Ganesh V, Jang A, Borges-Monroy R, Partlow JN, Hill RS, Shin T, Chen AY, Doan RN, Anttonen AK, Ignatius J, Medne L, Bönnemann CG, Hecht JL, Salonen O, Barkovich AJ, Poduri A, Wilke M, de Wit MC, Mancini GM, Sztriha L, Im K, Amrom D, Andermann E, Paetau R, Lehesjoki AE, Walsh CA, Lehtinen MK . 6. Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development . Neuron . 99 . 5 . 905–913.e7 . September 2018 . 30146301 . 10.1016/j.neuron.2018.07.052 . 6226006.