Nifurzide Explained
Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.[1]
Synthesis
Esterification of 5-nitrothiophene-2-carboxylic acid (1) with ethanol gives the ester (2). Treatment with hydrazine forms its hydrazide (3). Nifurzide is the hydrazone formed between (3) and 5-nitrofuran-2-acrylaldehyde (4).[2] [3] [4]
Notes and References
- Delsarte A, Faway M, Frère JM, Coyette J, Calberg-Bacq CM, Heinen E . Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells . Antimicrobial Agents and Chemotherapy . 19 . 3 . 477–86 . March 1981 . 7018391 . 181457 . 10.1128/aac.19.3.477 .
- US . 3847911 . patent . 1974-11-12 . 1972-01-05 . 1973-07-13 . Szarvasi E, Fontaine L . Novel substituted(nitrofurylacrylidene)hydrazines with antibacterial properties .
- Szarvasi E, Fontaine L, Betbeder-Matibet A . Antimicrobials. New nitrofuran derivatives . Journal of Medicinal Chemistry . 16 . 3 . 281–287 . March 1973 . 4200221 . 10.1021/jm00261a027 .
- Web site: Nifurzide . Pharmaceutical Substances . Thieme . 2024-07-02 .