OSBPL5 explained
Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.[1]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.
Further reading
- Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E . Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism . J. Lipid Res. . 40 . 12 . 2204–11 . 2000 . 10.1016/S0022-2275(20)32095-2 . 10588946 . free .
- Nagase T, Kikuno R, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 2 . 143–50 . 2000 . 10819331 . 10.1093/dnares/7.2.143 . free .
- Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
- Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
- Lehto M, Laitinen S, Chinetti G, etal . The OSBP-related protein family in humans . J. Lipid Res. . 42 . 8 . 1203–13 . 2001 . 10.1016/S0022-2275(20)31570-4 . 11483621 . free .
- Jaworski CJ, Moreira E, Li A, etal . A family of 12 human genes containing oxysterol-binding domains . Genomics . 78 . 3 . 185–96 . 2002 . 11735225 . 10.1006/geno.2001.6663 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Higashimoto K, Soejima H, Yatsuki H, etal . Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse . Genomics . 80 . 6 . 575–84 . 2003 . 12504849 . 10.1006/geno.2002.7006 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
- Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
- Ma J, Dempsey AA, Stamatiou D, etal . Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects . Atherosclerosis . 191 . 1 . 63–72 . 2007 . 16806233 . 10.1016/j.atherosclerosis.2006.05.032 .
- Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
Notes and References
- Web site: Entrez Gene: OSBPL5 oxysterol binding protein-like 5.