| Osage High School | |
| Location: | 636 Hwy 42 |
| Country: | United States |
| Zipcode: | 65065 |
| Type: | Public |
| Established: | 1933 |
| Staff: | 39.60 (FTE) |
| Ratio: | 16.82 |
| District: | School of the Osage R-II School District |
| Enrolment: | 666 (2022–23)[1] |
| Grades: | 9-12 |
| Colours: | Maroon & White |
| Mascot: | Indian |
| Conference: | Tri-County Conference |
| Principal: | David Dawson |
Osage High School (School of the Osage) is a secondary school located in Osage Beach, Missouri. Approximately 96% of the students who attend the school are Caucasian, 1% are Hispanic, and the small remainder are Native American or African-American. The student to teacher ratio is 15 to 1. The school features numerous organizations and sports, and is an MSHSAA member.