PARD6B explained
Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.[1] [2]
Function
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.
Interactions
PARD6B has been shown to interact with:
Further reading
- Joberty G, Petersen C, Gao L, Macara IG . The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 . Nat. Cell Biol. . 2 . 8 . 531–9 . 2000 . 10934474 . 10.1038/35019573 . 27139234 .
- Gao L, Macara IG, Joberty G . Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties . Gene . 294 . 1–2 . 99–107 . 2003 . 12234671 . 10.1016/S0378-1119(02)00681-9 .
- Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H . PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions . Biochem. Biophys. Res. Commun. . 299 . 4 . 641–6 . 2003 . 12459187 . 10.1016/S0006-291X(02)02698-0 .
- Hurd TW, Gao L, Roh MH, Macara IG, Margolis B . Direct interaction of two polarity complexes implicated in epithelial tight junction assembly . Nat. Cell Biol. . 5 . 2 . 137–42 . 2003 . 12545177 . 10.1038/ncb923 . 25212419 .
- Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S . Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity . Curr. Biol. . 13 . 9 . 734–43 . 2004 . 12725730 . 10.1016/S0960-9822(03)00244-6 . 18570360 . free .
- Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G . Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network . J. Biol. Chem. . 279 . 13 . 12804–11 . 2004 . 14676191 . 10.1074/jbc.M312171200 . free .
- Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL . Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator . Proc. Natl. Acad. Sci. U.S.A. . 102 . 5 . 1339–44 . 2005 . 15677324 . 547886 . 10.1073/pnas.0409578102 . 2005PNAS..102.1339L . free .
Notes and References
- Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H . Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C . Genes Cells . 6 . 2 . 107–19 . March 2001 . 11260256 . 10.1046/j.1365-2443.2001.00404.x . 8789941 . free .
- Web site: Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans).
- Neudauer CL, Joberty G, Macara IG . PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 . Biochem. Biophys. Res. Commun. . 280 . 2 . 541–7 . January 2001 . 11162552 . 10.1006/bbrc.2000.4160 .
- Joberty G, Petersen C, Gao L, Macara IG . The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 . Nat. Cell Biol. . 2 . 8 . 531–9 . August 2000 . 10934474 . 10.1038/35019573 . 27139234 .