PCSK4 explained
Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.[1] [2]
Further reading
- Seidah NG, Chrétien M, Day R . The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. . Biochimie . 76 . 3–4 . 197–209 . 1995 . 7819324 . 10.1016/0300-9084(94)90147-3 .
- Bassi DE, Mahloogi H, Klein-Szanto AJ . The proprotein convertases furin and PACE4 play a significant role in tumor progression . Mol. Carcinog. . 28 . 2 . 63–9 . 2000 . 10900462 . 10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C . 22849623 .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
- Malik S, Guermah M, Roeder RG . A dynamic model for PC4 coactivator function in RNA polymerase II transcription . Proc. Natl. Acad. Sci. U.S.A. . 95 . 5 . 2192–7 . 1998 . 9482861 . 10.1073/pnas.95.5.2192 . 19292 . 1998PNAS...95.2192M . free .
- Wang Z, Roeder RG . DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III . Mol. Cell . 1 . 5 . 749–57 . 1998 . 9660958 . 10.1016/S1097-2765(00)80074-X . free .
- Li M, Mbikay M, Nakayama K, etal . Prohormone convertase PC4 processes the precursor of PACAP in the testis . Ann. N. Y. Acad. Sci. . 921 . 333–9 . 2001 . 11193847 . 10.1111/j.1749-6632.2000.tb06988.x . 46125753 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Qiu Q, Basak A, Mbikay M, etal . Role of pro-IGF-II processing by proprotein convertase 4 in human placental development . Proc. Natl. Acad. Sci. U.S.A. . 102 . 31 . 11047–52 . 2005 . 16040806 . 10.1073/pnas.0502357102 . 1182422 . 2005PNAS..10211047Q . free .
Notes and References
- Mbikay M, Seidah NG, Chretien M, Simpson EM . Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human . Genomics . 26 . 1 . 123–9 . Jul 1995 . 7782070 . 10.1016/0888-7543(95)80090-9 .
- Web site: Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4.