PDZK1 explained
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.[1] [2]
Interactions
PDZK1 has been shown to interact with:
Related gene problems
Further reading
- White KE, Biber J, Murer H, Econs MJ . A PDZ domain-containing protein with homology to Diphor-1 maps to human chromosome 1q21 . Ann. Hum. Genet. . 62 . Pt 4 . 287–90 . 1999 . 9924606 . 10.1046/j.1469-1809.1998.6240287.x . free .
- Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH . PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein . Lab. Invest. . 79 . 9 . 1161–70 . 1999 . 10496535 .
- Ikemoto M, Arai H, Feng D, Tanaka K, Aoki J, Dohmae N, Takio K, Adachi H, Tsujimoto M, Inoue K . Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I . Proc. Natl. Acad. Sci. U.S.A. . 97 . 12 . 6538–43 . 2000 . 10829064 . 18651 . 10.1073/pnas.100114397 . 2000PNAS...97.6538I . free .
- Wang S, Yue H, Derin RB, Guggino WB, Li M . Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity . Cell . 103 . 1 . 169–79 . 2000 . 11051556 . 10.1016/S0092-8674(00)00096-9 . 16697781 . free .
- Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 310948 . 10.1101/gr.143000 .
- Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H . Interaction of the type IIa Na/Pi cotransporter with PDZ proteins . J. Biol. Chem. . 276 . 12 . 9206–13 . 2001 . 11099500 . 10.1074/jbc.M008745200 . free .
- Silver DL . A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver . J. Biol. Chem. . 277 . 37 . 34042–7 . 2002 . 12119305 . 10.1074/jbc.M206584200 . free .
- Sellin L, Huber TB, Gerke P, Quack I, Pavenstädt H, Walz G . NEPH1 defines a novel family of podocin interacting proteins . FASEB J. . 17 . 1 . 115–7 . 2003 . 12424224 . 10.1096/fj.02-0242fje . free . 17732086 .
- Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR . The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins . J. Biol. Chem. . 278 . 8 . 6440–9 . 2003 . 12471024 . 10.1074/jbc.M211050200 . free .
- Hegedüs T, Sessler T, Scott R, Thelin W, Bakos E, Váradi A, Szabó K, Homolya L, Milgram SL, Sarkadi B . C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins . Biochem. Biophys. Res. Commun. . 302 . 3 . 454–61 . 2003 . 12615054 . 10.1016/S0006-291X(03)00196-7 .
- Silver DL, Wang N, Vogel S . Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels . J. Biol. Chem. . 278 . 31 . 28528–32 . 2003 . 12754212 . 10.1074/jbc.M304109200 . free .
- Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H . Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells . Am. J. Physiol. Renal Physiol. . 285 . 4 . F784–91 . 2003 . 12837682 . 10.1152/ajprenal.00109.2003 . 25450845 .
- Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H . PDZK1: I. a major scaffolder in brush borders of proximal tubular cells . Kidney Int. . 64 . 5 . 1733–45 . 2004 . 14531806 . 10.1046/j.1523-1755.2003.00266.x . free .
- Kocher O, Yesilaltay A, Cirovic C, Pal R, Rigotti A, Krieger M . Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism . J. Biol. Chem. . 278 . 52 . 52820–5 . 2004 . 14551195 . 10.1074/jbc.M310482200 . free .
- Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J . Overexpression of PDZK1 within the 1q12-q22 Amplicon Is Likely To Be Associated with Drug-Resistance Phenotype in Multiple Myeloma . Am. J. Pathol. . 165 . 1 . 71–81 . 2004 . 15215163 . 1618545 . 10.1016/S0002-9440(10)63276-2 .
- Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K, Kanai Y, Endou H . The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus . J. Biol. Chem. . 279 . 44 . 45942–50 . 2004 . 15304510 . 10.1074/jbc.M406724200 . free .
Notes and References
- Kocher O, Comella N, Tognazzi K, Brown LF . Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains . Lab Invest . 78 . 1 . 117–25 . March 1998 . 9461128 .
- Web site: Entrez Gene: PDZK1 PDZ domain containing 1.
- Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H . PDZK1: I. a major scaffolder in brush borders of proximal tubular cells . Kidney Int. . 64 . 5 . 1733–45 . November 2003 . 14531806 . 10.1046/j.1523-1755.2003.00266.x . free .
- Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR . The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins . J. Biol. Chem. . 278 . 8 . 6440–9 . February 2003 . 12471024 . 10.1074/jbc.M211050200 . free .
- Wang S, Yue H, Derin RB, Guggino WB, Li M . Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity . Cell . 103 . 1 . 169–79 . September 2000 . 11051556 . 10.1016/s0092-8674(00)00096-9. 16697781 . free .
- Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H . Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells . Am. J. Physiol. Renal Physiol. . 285 . 4 . F784-91 . October 2003 . 12837682 . 10.1152/ajprenal.00109.2003 . 25450845 .
- Silver DL, Wang N, Vogel S . Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels . J. Biol. Chem. . 278 . 31 . 28528–32 . August 2003 . 12754212 . 10.1074/jbc.M304109200 . free .
- Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S . Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome . Am. J. Hum. Genet. . 80 . 2 . 232–40 . February 2007 . 17236129 . 1785342 . 10.1086/510919 .