POLR2J explained
DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene.
Function
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13.[1]
Interactions
POLR2J has been shown to interact with:
References
Further reading
- Jeang KT . Tat, Tat-associated kinase, and transcription. . J. Biomed. Sci. . 5 . 1 . 24–7 . 1998 . 9570510 . 10.1007/BF02253352 .
- Yankulov K, Bentley D . Transcriptional control: Tat cofactors and transcriptional elongation. . Curr. Biol. . 8 . 13 . R447–9 . 1998 . 9651670 . 10.1016/S0960-9822(98)70289-1 . 15480646 . free . 1998CBio....8.R447Y .
- Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A . Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. . J. Cell. Biochem. . 75 . 3 . 357–68 . 2000 . 10536359 . 10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K . 43685090 .
- Marcello A, Zoppé M, Giacca M . Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. . IUBMB Life . 51 . 3 . 175–81 . 2002 . 11547919 . 10.1080/152165401753544241 . 10931640 . free .
- Stevens M, De Clercq E, Balzarini J . The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. . Med Res Rev . 26 . 5 . 595–625 . 2007 . 16838299 . 10.1002/med.20081 . 7168390 .
- Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L . Will diverse Tat interactions lead to novel antiretroviral drug targets? . Current Drug Targets . 7 . 12 . 1595–606 . 2007 . 17168834 . 10.2174/138945006779025338 .
- Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG . HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. . Genes Dev. . 6 . 4 . 655–66 . 1992 . 1559613 . 10.1101/gad.6.4.655 . free .
- Southgate C, Zapp ML, Green MR . Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein. . Nature . 345 . 6276 . 640–2 . 1990 . 2190099 . 10.1038/345640a0 . 1990Natur.345..640S . 4233742 .
- Richard Gaynor . Wu-Baer F, Sigman D, Gaynor RB . Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat . Proc. Natl. Acad. Sci. U.S.A. . 92 . 16 . 7153–7 . 1995 . 7638159 . 41297 . 10.1073/pnas.92.16.7153 . 1995PNAS...92.7153W . free .
- Herrmann CH, Rice AP . Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor . J. Virol. . 69 . 3 . 1612–20 . 1995 . 7853496 . 188757 . 10.1128/JVI.69.3.1612-1620.1995.
- Keen NJ, Gait MJ, Karn J . Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex . Proc. Natl. Acad. Sci. U.S.A. . 93 . 6 . 2505–10 . 1996 . 8637904 . 39827 . 10.1073/pnas.93.6.2505 . 1996PNAS...93.2505K . free .
- Yang X, Herrmann CH, Rice AP . The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function . J. Virol. . 70 . 7 . 4576–84 . 1996 . 8676484 . 190394 . 10.1128/JVI.70.7.4576-4584.1996.
- Fanciulli M, Bruno T, Cerboni C, Bonetto F, Iacobini C, Frati L, Piccoli M, Floridi A, Santoni A, Punturieri A . Cloning of a novel human RNA polymerase II subunit downregulated by doxorubicin: new potential mechanisms of drug related toxicity . FEBS Lett. . 384 . 1 . 48–52 . 1996 . 8797801 . 10.1016/0014-5793(96)00277-3 . 7809458 .
- Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J . The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB . J. Mol. Biol. . 261 . 5 . 599–606 . 1996 . 8800208 . 10.1006/jmbi.1996.0485 .
- Zhou Q, Sharp PA . Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat . Science . 274 . 5287 . 605–10 . 1996 . 8849451 . 10.1126/science.274.5287.605 . 1996Sci...274..605Z . 13266489 .
- Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM . Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II . Proc. Natl. Acad. Sci. U.S.A. . 93 . 21 . 11575–9 . 1996 . 8876177 . 38099 . 10.1073/pnas.93.21.11575 . 1996PNAS...9311575O . free .
- Chun RF, Jeang KT . Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1 . J. Biol. Chem. . 271 . 44 . 27888–94 . 1996 . 8910388 . 10.1074/jbc.271.44.27888 . free .
- Parada CA, Roeder RG . Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain . Nature . 384 . 6607 . 375–8 . 1996 . 8934526 . 10.1038/384375a0 . 1996Natur.384..375P . 4278432 .
- García-Martínez LF, Ivanov D, Gaynor RB . Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes . J. Biol. Chem. . 272 . 11 . 6951–8 . 1997 . 9054383 . 10.1074/jbc.272.11.6951 . free .
- Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM . The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme . Mol. Cell. Biol. . 17 . 4 . 1817–23 . 1997 . 9121429 . 232028 . 10.1128/mcb.17.4.1817.
Notes and References
- Web site: Entrez Gene: POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa.
- Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C . Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb . FASEB J. . 14 . 7 . 904–12 . May 2000 . 10783144 . 10.1096/fasebj.14.7.904. free . 43175069 .
- Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M . Interactions between the human RNA polymerase II subunits . J. Biol. Chem. . 272 . 27 . 16815–21 . July 1997 . 9201987 . 10.1074/jbc.272.27.16815. free .
- Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, Floridi A, Fanciulli M, Passananti C . The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin . FASEB J. . 16 . 12 . 1639–41 . October 2002 . 12207009 . 10.1096/fj.02-0123fje . free . 30243193 .
- Durrin LK, Krontiris TG . The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11 . Genomics . 79 . 6 . 809–17 . June 2002 . 12036295 . 10.1006/geno.2002.6772 .