PRKACG explained
cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.[1] [2] [3]
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.
Interactions
PRKACG has been shown to interact with Ryanodine receptor 2.[4]
Further reading
- Foss KB . Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13 . Cytogenet. Cell Genet. . 60 . 1 . 22–5 . 1992 . 1339328 . 10.1159/000133286 . Simard J . Bérubé D . Beebe . S.J. . Sandberg . M. . Grzeschik . K.-H. . Gagné . R. . Hansson . V. . Jahnsen . T. .
- Hofmann B . HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism . J. Immunol. . 145 . 11 . 3699–705 . 1991 . 1978848 . Nishanian P . Baldwin RL . Insixiengmay . P . Nel . A . Fahey . JL . 10.4049/jimmunol.145.11.3699 . free.
- Hofmann B . Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes . Proc. Natl. Acad. Sci. U.S.A. . 90 . 14 . 6676–80 . 1993 . 7688126 . 10.1073/pnas.90.14.6676 . 46995 . Nishanian P . Nguyen T . Insixiengmay . P . Fahey . JL . 1993PNAS...90.6676H. free .
- Hofmann B . HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro . AIDS . 8 . 7 . 1016–7 . 1994 . 7946090 . 10.1097/00002030-199407000-00025 . Nishanian P . Fan J . Nguyen . T. . Fahey . J. L. .
- Swingler S . The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix . J. Virol. . 71 . 6 . 4372–7 . 1997 . 9151826 . 10.1128/JVI.71.6.4372-4377.1997. 191654 . Gallay P . Camaur D . Song . J . Abo . A . Trono . D .
- Chen P, Mayne M, Power C, Nath A . The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases . J. Biol. Chem. . 272 . 36 . 22385–8 . 1997 . 9278385 . 10.1074/jbc.272.36.22385 . free .
- Liapi C . Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts . J. Invest. Dermatol. . 110 . 4 . 332–7 . 1998 . 9540970 . 10.1046/j.1523-1747.1998.00149.x . Takahashi N . Raynaud F . Evain-Brion . Daniele . Anderson . Wayne B. . free .
- Zidovetzki R . Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways . AIDS Res. Hum. Retroviruses . 14 . 10 . 825–33 . 1998 . 9671211 . 10.1089/aid.1998.14.825 . Wang JL . Chen P . Jeyaseelan . Raju . Hofman . Florence .
- Mayne M . HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease . Neuroimmunomodulation . 5 . 3–4 . 184–92 . 1998 . 9730685 . 10.1159/000026336 . Bratanich AC . Chen P . Rana . Farazana . Nath . Avindra . Power . Christopher . 19529677 .
- Bodnar RJ . Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta) . J. Biol. Chem. . 277 . 49 . 47080–7 . 2003 . 12361948 . 10.1074/jbc.M208329200 . Xi X . Li Z . Berndt . MC . Du . X . free .
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
- Cartier C . Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein . J. Biol. Chem. . 278 . 37 . 35211–9 . 2003 . 12842892 . 10.1074/jbc.M301257200 . Hemonnot B . Gay B . Bardy . M . Sanchiz . C . Devaux . C . Briant . L . free .
- Masci AM . HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling . J. Leukoc. Biol. . 74 . 6 . 1117–24 . 2004 . 12972513 . 10.1189/jlb.0503239 . Galgani M . Cassano S . De Simone . S . Gallo . A . De Rosa . V . Zappacosta . S . Racioppi . L . 13393007 . free .
- Zhang W, Morris GZ, Beebe SJ . Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells . Protein Expr. Purif. . 35 . 1 . 156–69 . 2004 . 15039079 . 10.1016/j.pep.2004.01.006 .
- Stevanin G . Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14 . Arch. Neurol. . 61 . 8 . 1242–8 . 2004 . 15313841 . 10.1001/archneur.61.8.1242 . Hahn V . Lohmann E . Bouslam . N . Gouttard . M . Soumphonphakdy . C . Welter . ML . Ollagnon-Roman . E . Lemainque . A . free .
- Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
Notes and References
- Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T . Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase . Mol Endocrinol . 4 . 3 . 465–75 . June 1990 . 2342480 . 10.1210/mend-4-3-465 . free .
- Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K . The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon . Genomics . 49 . 2 . 290–7 . August 1998 . 9598317 . 10.1006/geno.1998.5240 .
- Web site: Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma.
- Marx . S O . Reiken S . Hisamatsu Y . Jayaraman T . Burkhoff D . Rosemblit N . Marks A R . May 2000 . PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts . Cell . 101 . 4 . 365–76 . UNITED STATES. 0092-8674. 10830164 . 10.1016/S0092-8674(00)80847-8 . 6496567 . free .