SESN1 explained
Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[1] [2] [3]
See also
Further reading
- Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM . Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD . Science . 304 . 5670 . 596–600 . April 2004 . 15105503 . 10.1126/science.1095569 . 2004Sci...304..596B . 27871118 .
- Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K . PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse . Human Genetics . 112 . 5–6 . 573–80 . May 2003 . 12607115 . 10.1007/s00439-003-0917-5 . 22257894 .
- Jing, Y., Zuo, Y., Sun, L., Yu, Z. R., Ma, S., Hu, H., ... & Wang, S. (2023). "SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing". Cell Proliferation, e13455.
Notes and References
- Web site: Entrez Gene: sestrin 1.
- Buckbinder L, Talbott R, Seizinger BR, Kley N . Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes . Proceedings of the National Academy of Sciences of the United States of America . 91 . 22 . 10640–4 . October 1994 . 7938006 . 45077 . 10.1073/pnas.91.22.10640 . 1994PNAS...9110640B . free .
- Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N . PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes . Oncogene . 18 . 1 . 127–37 . January 1999 . 9926927 . 10.1038/sj.onc.1202274 . free .