Mitochondrial 2-oxoglutarate/malate carrier protein explained
Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene.[1] [2] [3] Inactivating mutations in this gene predispose to metastasic paraganglioma.[4]
See also
Further reading
- Bisaccia F, Zara V, Capobianco L, etal . The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier . Biochim. Biophys. Acta . 1292 . 2 . 281–88 . 1996 . 8597574 . 10.1016/0167-4838(95)00215-4 .
- Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
- Bisaccia F, Capobianco L, Mazzeo M, Palmieri F . The mitochondrial oxoglutarate carrier protein contains a disulfide bridge between intramembranous cysteines 221 and 224 . FEBS Lett. . 392 . 1 . 54–8 . 1996 . 8769314 . 10.1016/0014-5793(96)00784-3 . 46276462 .
- Yu W, Andersson B, Worley KC, etal . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
- Palmisano A, Zara V, Hönlinger A, etal . Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane . Biochem. J. . 333 (Pt 1) . Pt 1. 151–8 . 1998 . 9639574 . 10.1042/bj3330151. 1219567 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Coll O, Colell A, García-Ruiz C, etal . Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion . Hepatology . 38 . 3 . 692–702 . 2003 . 12939596 . 10.1053/jhep.2003.50351 . 10261/111821 . 2128549 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Kabe Y, Ohmori M, Shinouchi K, etal . Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier . J. Biol. Chem. . 281 . 42 . 31729–35 . 2006 . 16920706 . 10.1074/jbc.M604729200 . free.
Notes and References
- Piccininni S, Iacobazzi V, Lauria G, Rocchi M, Palmieri F . Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3 . Cytogenet Cell Genet . 83 . 3–4 . 256–7 . Mar 1999 . 10072597 . 10.1159/000015198 . 36221506 .
- Iacobazzi V, Palmieri F, Runswick MJ, Walker JE . Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier . DNA Seq . 3 . 2 . 79–88 . Jan 1993 . 1457818 . 10.3109/10425179209034000.
- Web site: Entrez Gene: SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11.
- Buffet. Alexandre. Morin. Aurelie. Castro-Vega. Luis-Jaime. Habarou. Florence. Lussey-Lepoutre. Charlotte. Letouzé. Eric. Lefebvre. Hervé. Guilhem. Isabelle. Magalie. Haissaguerre. 2018-02-05. Germline mutations in the mitochondrial 2-oxoglutarate/malate carrier SLC25A11 gene confer a predisposition to metastatic paragangliomas. Cancer Research. 78. 8. 1914–1922. 10.1158/0008-5472.CAN-17-2463. 1538-7445. 29431636. free.