SNX27 explained
Sorting nexin family member 27, also known as SNX27, is a human gene.[1]
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
Further reading
- Worby CA, Dixon JE . Sorting out the cellular functions of sorting nexins . Nature Reviews. Molecular Cell Biology . 3 . 12 . 919–31 . December 2002 . 12461558 . 10.1038/nrm974 . 36361630 .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
- Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O . Characterization of cDNA clones in size-fractionated cDNA libraries from human brain . DNA Research . 4 . 5 . 345–9 . October 1997 . 9455484 . 10.1093/dnares/4.5.345 . free .
- Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA . A large family of endosome-localized proteins related to sorting nexin 1 . The Biochemical Journal . 358 . Pt 1 . 7–16 . August 2001 . 11485546 . 1222026 . 10.1042/0264-6021:3580007 .
- Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF . Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin . Molecular Biology of the Cell . 15 . 7 . 3095–105 . July 2004 . 15121882 . 452567 . 10.1091/mbc.E04-02-0143 .
- Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J . New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting . Journal of Cell Science . 117 . Pt 22 . 5367–79 . October 2004 . 15466885 . 10.1242/jcs.01379 . free .
- Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I . Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling . Molecular & Cellular Proteomics . 6 . 6 . 1073–87 . June 2007 . 17351151 . 10.1074/mcp.M700047-MCP200 . free .
- MacNeil AJ, Mansour M, Pohajdak B . Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes . Biochemical and Biophysical Research Communications . 359 . 4 . 848–53 . August 2007 . 17577583 . 10.1016/j.bbrc.2007.05.162 .
Notes and References
- Web site: Entrez Gene: SNX27 sorting nexin family member 27.