SOX4 explained
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[1] [2] [3]
Function
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.
Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.[4]
Clinical significance
A genomic region close to the SOX4 gene has been associated with endometrial cancer development.[5] [6]
Interactions
SOX4 has been shown to interact with SDCBP.[7]
See also
Further reading
- Kamachi Y, Uchikawa M, Kondoh H . Pairing SOX off: with partners in the regulation of embryonic development . Trends in Genetics . 16 . 4 . 182–7 . April 2000 . 10729834 . 10.1016/S0168-9525(99)01955-1 .
- Bowles J, Schepers G, Koopman P . Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators . Developmental Biology . 227 . 2 . 239–55 . November 2000 . 11071752 . 10.1006/dbio.2000.9883 . free .
- Wilson M, Koopman P . Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators . Current Opinion in Genetics & Development . 12 . 4 . 441–6 . August 2002 . 12100890 . 10.1016/S0959-437X(02)00323-4 .
- Schepers GE, Teasdale RD, Koopman P . Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families . Developmental Cell . 3 . 2 . 167–70 . August 2002 . 12194848 . 10.1016/S1534-5807(02)00223-X . free .
- Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A . A conserved family of genes related to the testis determining gene, SRY . Nucleic Acids Research . 20 . 11 . 2887 . June 1992 . 1614875 . 336939 . 10.1093/nar/20.11.2887 .
- Wotton D, Lake RA, Farr CJ, Owen MJ . The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer . The Journal of Biological Chemistry . 270 . 13 . 7515–22 . March 1995 . 7706298 . 10.1074/jbc.270.13.7515 . free .
- van de Wetering M, Oosterwegel M, van Norren K, Clevers H . Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes . The EMBO Journal . 12 . 10 . 3847–54 . October 1993 . 8404853 . 413668 . 10.1002/j.1460-2075.1993.tb06063.x.
- van Houte LP, Chuprina VP, van der Wetering M, Boelens R, Kaptein R, Clevers H . Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4 . The Journal of Biological Chemistry . 270 . 51 . 30516–24 . December 1995 . 8530483 . 10.1074/jbc.270.51.30516 . free .
- Ahn SG, Cho GH, Jeong SY, Rhim H, Choi JY, Kim IK . Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells . Biochemical and Biophysical Research Communications . 260 . 1 . 216–21 . June 1999 . 10381369 . 10.1006/bbrc.1999.0856 .
- van Beest M, Dooijes D, van De Wetering M, Kjaerulff S, Bonvin A, Nielsen O, Clevers H . Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs . The Journal of Biological Chemistry . 275 . 35 . 27266–73 . September 2000 . 10867006 . 10.1074/jbc.M004102200 . free .
- Reppe S, Rian E, Jemtland R, Olstad OK, Gautvik VT, Gautvik KM . Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells . Journal of Bone and Mineral Research . 15 . 12 . 2402–12 . December 2000 . 11127205 . 10.1359/jbmr.2000.15.12.2402 . 2013715 .
- Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ . Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein . Science . 293 . 5532 . 1136–8 . August 2001 . 11498591 . 10.1126/science.1059157 . 28003281 .
- Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ . Differential expression of SOX4 and SOX11 in medulloblastoma . Journal of Neuro-Oncology . 57 . 3 . 201–14 . May 2002 . 12125983 . 10.1023/A:1015773818302 . 20719302 .
- Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim H, Shim JY, Kim JW, Lee JH, Kim IK . Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2) . Experimental & Molecular Medicine . 34 . 3 . 243–9 . July 2002 . 12216117 . 10.1038/emm.2002.34 . free .
Notes and References
- Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN . Characterization and mapping of the human SOX4 gene . Mammalian Genome . 4 . 10 . 577–84 . January 1994 . 8268656 . 10.1007/BF00361388 . 12096721 .
- Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ . Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3 . Cytogenetics and Cell Genetics . 81 . 3–4 . 294–5 . October 1998 . 9730625 . 10.1159/000015052 . 2024-07-25 . 46849443 .
- Web site: Entrez Gene: SOX4 SRY (sex determining region Y)-box 4.
- Smith E, Sigvardsson M . The roles of transcription factors in B lymphocyte commitment, development, and transformation . Journal of Leukocyte Biology . 75 . 6 . 973–81 . June 2004 . 14982952 . 10.1189/jlb.1103554 . 6805071 .
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