TENC1 explained
Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[1]
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Interactions
TENC1 has been shown to interact with AXL receptor tyrosine kinase.[2]
Further reading
- Kikuno R, Nagase T, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 3 . 197–205 . 1999 . 10470851 . 10.1093/dnares/6.3.197 . free .
- Chen H, Duncan IC, Bozorgchami H, Lo SH . Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 2 . 733–8 . 2002 . 11792844 . 10.1073/pnas.022518699 . 117374 . 2002PNAS...99..733C . free .
- Hafizi S, Alindri F, Karlsson R, Dahlbäck B . Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. . Biochem. Biophys. Res. Commun. . 299 . 5 . 793–800 . 2003 . 12470648 . 10.1016/S0006-291X(02)02718-3 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Calderwood DA, Fujioka Y, de Pereda JM, etal . Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 5 . 2272–7 . 2003 . 12606711 . 10.1073/pnas.262791999 . 151330 . 2003PNAS..100.2272C . free .
- Hu Y, Fang X, Dunham SM, etal . 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. . J. Biol. Chem. . 279 . 28 . 29325–35 . 2004 . 15117958 . 10.1074/jbc.M311144200 . free .
- Hafizi S, Ibraimi F, Dahlbäck B . C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. . FASEB J. . 19 . 8 . 971–3 . 2006 . 15817639 . 10.1096/fj.04-2532fje . free . 42601912 .
- Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
- Yam JW, Ko FC, Chan CY, etal . Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma. . Hepatology . 44 . 4 . 881–90 . 2006 . 17006924 . 10.1002/hep.21339 . 10376927 .
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Tensin-2
Notes and References
- Web site: Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2).
- 10.1016/S0006-291X(02)02718-3 . Hafizi . Sassan . Alindri Filiz . Karlsson Roger . Dahlbäck Björn . Dec 2002 . Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin . Biochem. Biophys. Res. Commun. . 299 . 5 . 793–800 . United States. 0006-291X. 12470648 .