TM4SF5 explained
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[1] [2]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.
Further reading
- Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye . J. Cell Sci. . 114 . Pt 23 . 4143–51 . 2002 . 10.1242/jcs.114.23.4143 . 11739647 .
- Lee SY . Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment . Exp. Cell Res. . 312 . 16 . 2983–99 . 2006 . 16828471 . 10.1016/j.yexcr.2006.06.001 . vanc. Kim YT . Lee MS . 3 . Kim . Yong-Bae . Chung . Eunji . Kim . Semi . Lee . Jung Weon . 10371/3238 . free.
- Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
- Kaneko R . Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa . Am. J. Gastroenterol. . 96 . 12 . 3457–8 . 2002 . 11774983 . vanc. Tsuji N . Kamagata C . 3 . Endoh . Teruo . Nakamura . Masashi . Kobayashi . Daisuke . Yagihashi . Atsuhito . Watanabe . Naoki . 10.1111/j.1572-0241.2001.05355.x . 31864317 .
- Wright MD, Ni J, Rudy GB . The L6 membrane proteins--a new four-transmembrane superfamily . Protein Sci. . 9 . 8 . 1594–600 . 2000 . 10975581 . 10.1110/ps.9.8.1594 . 2144728 .
- Gress TM . A pancreatic cancer-specific expression profile . Oncogene . 13 . 8 . 1819–30 . 1996 . 8895530 . vanc. Müller-Pillasch F . Geng M . 3 . Zimmerhackl . F . Zehetner . G . Friess . H . Büchler . M . Adler . G . Lehrach . H .
Notes and References
- Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM . Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer . Gene . 208 . 1 . 25–30 . Mar 1998 . 9479038 . 10.1016/S0378-1119(97)00633-1 .
- Web site: Entrez Gene: TM4SF5 transmembrane 4 L six family member 5.