TUFM explained
Elongation factor Tu, mitochondrial is a protein that in humans is encoded by the TUFM gene. It is an EF-Tu homolog.[1] [2] [3]
Further reading
- Wells J, Henkler F, Leversha M, Koshy R . A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues. . FEBS Lett. . 358 . 2 . 119–25 . 1995 . 7828719 . 10.1016/0014-5793(94)01403-N . 24769779 . free .
- Woriax VL, Burkhart W, Spremulli LL . Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu. . Biochim. Biophys. Acta . 1264 . 3 . 347–56 . 1996 . 8547323 . 10.1016/0167-4781(95)00176-x.
- Chang SY, Park SG, Kim S, Kang CY . Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. . J. Biol. Chem. . 277 . 10 . 8388–94 . 2002 . 11741979 . 10.1074/jbc.M108792200 . free .
- Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Blagoev B, Kratchmarova I, Ong SE, etal . A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. . Nat. Biotechnol. . 21 . 3 . 315–8 . 2003 . 12577067 . 10.1038/nbt790 . 26838266 .
- Gevaert K, Goethals M, Martens L, etal . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
- Ahmed M, Forsberg J, Bergsten P . Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. . J. Proteome Res. . 4 . 3 . 931–40 . 2005 . 15952740 . 10.1021/pr050024a .
- Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA . The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1. . Hum. Mol. Genet. . 15 . 11 . 1835–46 . 2006 . 16632485 . 10.1093/hmg/ddl106 . free .
- Smeitink JA, Elpeleg O, Antonicka H, etal . Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs. . Am. J. Hum. Genet. . 79 . 5 . 869–77 . 2006 . 17033963 . 10.1086/508434 . 1698578 .
- Valente L, Tiranti V, Marsano RM, etal . Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. . Am. J. Hum. Genet. . 80 . 1 . 44–58 . 2007 . 17160893 . 10.1086/510559 . 1785320 .
- Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
Notes and References
- Ling M, Merante F, Chen HS, Duff C, Duncan AM, Robinson BH . The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene . Gene . 197 . 1–2 . 325–36 . Nov 1997 . 9332382 . 10.1016/S0378-1119(97)00279-5 .
- Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT . Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus . Genomics . 48 . 3 . 384–8 . Jun 1998 . 9545647 . 10.1006/geno.1997.5166 .
- Web site: Entrez Gene: TUFM Tu translation elongation factor, mitochondrial.