| Tuneros de San Luis Potosí | |
| Established: | 1946 |
| Folded: | 2007 |
| Location: | San Luis Potosí, San Luis Potosí |
| League: | Mexican League (1946–2006) |
| Colors: | Blue and gold |
| Ballpark: | Estadio 20 de Noviembre |
| H Cap: | 0000C4 |
| H Pattern B: | _baseball |
| H Body: | FFFFFF |
| H Leftarm: | FFFFFF |
| H Rightarm: | FFFFFF |
| H Pattern Pants: | _bluebelt |
| H Pants: | FFFFFF |
| H Socks: | 0000C4 |
The Tuneros de San Luis Potosí (English: San Luis Potosí Prickly Pear Pickers) were a professional baseball team in the Mexican League based in San Luis Potosí, Mexico. The club played during 16 seasons spanning 1946–2006.
The first Tuneros team played from 1946 through 1952 in the Mexican League. After 13 years of absence, another club with a similar name played in the Mexican Central League from 1960–1962 and once more in 1971. Then, they joined the expanded Mexican League from 1986–1990; played as the Reales de San Luis Potosí in 1991, and again as the Tuneros from 2004–2006.
The Tuneros enjoyed their only winning season in 1971, when they won the MCL Central Division title with a 45–27 record but lost the final Series. After that, no team from San Luis Potosí has ever won a title in Mexican baseball.