Tylvalosin Explained

Width:250
Tradename:Aiviosin
Dailymedid:Tylvalosin
Routes Of Administration:By mouth
Class:Macrolide antibiotic
Atcvet:Yes
Atc Prefix:J01
Atc Suffix:FA92
Legal Us:Rx-only
Legal Us Comment:[1] [2] [3]
Index2 Label:as tartrate
Cas Number:63409-12-1
Cas Number2:63428-13-7
Pubchem:6441094
Drugbank:DB11554
Drugbank2:DBSALT001708
Chemspiderid:4945313
Chemspiderid2:30790860
Unii:9T02S42WQO
Unii2:AL5667FY0W
Kegg:D10032
Kegg2:D10034
Chembl:2103834
C:53
H:87
N:1
O:19
Smiles:CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC
Smiles2:O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC
Stdinchi:1S/C53H87NO19/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3/b18-17+,28-22+/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-/m1/s1
Stdinchi2:1S/C53H87NO19.C4H6O6/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3;5-1(3(7)8)2(6)4(9)10/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3;1-2,5-6H,(H,7,8)(H,9,10)/b18-17+,28-22+;/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-;1-,2-/m11/s1
Stdinchikey:KCJJINQANFZSAM-HZDSEHBESA-N
Stdinchikey2:OLLSDNUHBJHKJS-XKORHJEPSA-N

Tylvalosin, sold under the brand name Aiviosin, is a macrolide antibiotic used for the treatment of bacterial infections with Mycoplasma hyopneumoniae in swine, that causes enzootic pneumonia.[4] It is used as tylvalosin tartrate.

Mechanism of Action

Macrolides are generally considered to be bacteriostatic agents that exert their antibiotic effect by reversibly binding to the 23S rRNA of the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis.[5]

Medical uses

Tylvalosin is indicated for the control of porcine proliferative enteropathy associated with Lawsonia intracellularis infection in groups of swine intended for slaughter and female swine intended for breeding in buildings experiencing an outbreak of PPE. Not for use in male swine intended for breeding; and for the control of swine respiratory disease associated with Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis, and Mycoplasma hyopneumoniae in groups of swine intended for slaughter and female swine intended for breeding in buildings experiencing an outbreak of swine respiratory disease. Not for use in male swine intended for breeding.

Notes and References

  1. Web site: Aiviosin- tylvalosin granule . DailyMed . 29 November 2021 . 13 December 2023.
  2. Web site: Aiviosin- tylvalosin tartrate granule, for solution . DailyMed . 29 November 2021 . 13 December 2023.
  3. Web site: Freedom of Information Summary Aiviosin NADA 141-336 . PDF . 13 December 2023 .
  4. Web site: Tylvalosin . 2024-06-28 . TOKU-E . en.
  5. Web site: Tylvalosin . 2024-06-28 . TOKU-E . en.