UNC5C explained
Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.[1] [2] [3]
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.[3]
Further reading
- Kennedy TE . Cellular mechanisms of netrin function: long-range and short-range actions. . Biochem. Cell Biol. . 78 . 5 . 569–75 . 2001 . 11103947 . 10.1139/bcb-78-5-569 .
- Livesey FJ . Netrins and netrin receptors. . Cell. Mol. Life Sci. . 56 . 1–2 . 62–8 . 2001 . 11213262 . 10.1007/s000180050006 . 33776808 . 11146895 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Thiebault K, Mazelin L, Pays L, etal . The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment . Proc. Natl. Acad. Sci. U.S.A. . 100 . 7 . 4173–8 . 2003 . 12655055 . 10.1073/pnas.0738063100 . 153067 . 2003PNAS..100.4173T . free .
- Geisbrecht BV, Dowd KA, Barfield RW, etal . Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin . J. Biol. Chem. . 278 . 35 . 32561–8 . 2003 . 12810718 . 10.1074/jbc.M302943200 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Kruger RP, Lee J, Li W, Guan KL . Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation . J. Neurosci. . 24 . 48 . 10826–34 . 2005 . 15574733 . 10.1523/JNEUROSCI.3715-04.2004 . 6730211 . free .
- Llambi F, Lourenço FC, Gozuacik D, etal . The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase . EMBO J. . 24 . 6 . 1192–201 . 2005 . 15729359 . 10.1038/sj.emboj.7600584 . 556396 .
- Bernet A, Mazelin L, Coissieux MM, etal . Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies . Gastroenterology . 133 . 6 . 1840–8 . 2008 . 17967459 . 10.1053/j.gastro.2007.08.009 . 2211510 .
Notes and References
- Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M . Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors . Nature . 386 . 6627 . 833–8 . May 1997 . 9126742 . 10.1038/386833a0 . 1997Natur.386..833L . 1232956 .
- Ackerman SL, Knowles BB . Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23 . Genomics . 52 . 2 . 205–8 . Dec 1998 . 9782087 . 10.1006/geno.1998.5425 .
- Web site: Entrez Gene: UNC5C unc-5 homolog C (C. elegans).